High-Throughput ADME Service
Creative Biolabs' High-Throughput ADME Service helps you accelerate drug discovery and eliminate weak drug candidates before clinical development through advanced high-throughput screening platforms and expert LC-MS/MS bioanalysis. By leveraging our high-throughput ADME platform, our clients can quickly identify lead candidates with favorable ADME profiles, leading to faster advancements in biologics-based therapies. We provide the decisive, early-stage insight necessary to transform promising hits into marketable drug candidates, ensuring your resources are focused only on the most viable molecules.
Introduction What We Can Offer How We Can Help Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
High-Throughput ADME Service -- Early ADME Testing for De-Risking Drug Development
In vitro high-throughput ADME studies utilize advanced technology platforms and automated systems to quickly assess the pharmacokinetic properties of a large number of molecules or compounds. High-throughput ADME platforms are crucial for accelerating the drug development pipeline and improving the success rate of bringing new drugs to market. This approach allows researchers to identify promising drug candidates early in the drug discovery process, thus saving time and resources.
Discover how we can help - We invite you to reach out for a detailed discussion about your specific project needs.
What We Can Offer
Our high-throughput ADME platforms are equipped with state-of-the-art instrumentation and automated sample-handling systems. This ensures accurate, reproducible, and consistent results, enabling us to provide reliable data to support your drug development programs. Whether you need to screen a library of therapeutic proteins or antibodies for ADME properties or perform detailed profiling of individual drug candidates, our team of experienced scientists is ready to assist you. We offer the following high-throughput ADME assays, including but not limited to:
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Solubility/Permeability Assays
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Metabolic Stability Assays (hepatocytes, microsomes, or plasma stability)
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Protein Binding Assays (plasma, microsomes, tissue)
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CYP Reaction Phenotyping Assays
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CYP inhibition Assays
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RBC partitioning (blood/plasma ratio)
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Our High-Throughput ADME Platforms
Highlights
Accelerated Processing
Our high-throughput ADME platforms are designed to process a large number of samples quickly and efficiently. This allows for accelerated drug discovery and development timelines, improving overall efficiency.
Accuracy and Consistency
Our platforms ensure accurate, reproducible, and consistent results, providing high-fidelity data that you can trust for critical decision-making in your drug pipeline.
Customized Solutions
Our high-throughput ADME facility offers fully customizable services to meet your specific needs. We adapt protocols to suit your molecule type, stage of research, and required output.
Expert Scientific Support
Our team of experienced scientists offers comprehensive technology support. Whether you require assistance with experimental design, data analysis, or interpretation, our experts are here to help.
To capitalize on the Creative Biolabs' competitive advantages, submit a formal request for quotation today.
Customer Reviews
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Clear Prediction of Human Clearance
Using Creative Biolabs' high-throughput ADME service in our research has significantly improved the accuracy of predicting human Clint across our small molecule library, helping us prioritize scaffolds early. - Dr. A**da P***rs
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Reliable IC50 Data
The quality and reproducibility of the IC50 values for CYP inhibition are exceptional. This reliable data, generated in less than 7 days, has greatly facilitated our ability to design non-inhibitory analogs. - J**n S***th, Process Chemist.
FAQs
Q: How does the HT-ADME approach improve upon traditional ADME screening?
A: Traditional screening is slow and sequential. Our HT-ADME approach is parallel and highly automated, allowing us to test hundreds of compounds simultaneously with high fidelity. This enables the elimination of weak candidates much earlier, when the investment is minimal.
Q: Are you able to handle compounds that require specialized analytical methods, such as peptides?
A: Yes, our platform is fully equipped with HRMS and specialized LC-MS/MS methods to address the unique challenges of non-small molecule therapeutics, including peptide drug candidates and biologics, ensuring accurate characterization of their metabolism and stability.
Related Services
In Vivo PD
Essential for linking drug exposure to therapeutic effect, this service measures target engagement, biomarker changes, and efficacy endpoints in relevant animal models to establish effective dose ranges.
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In Vivo PK
Determines the systemic fate of your drug in animal models, providing key pharmacokinetic parameters and bioavailability to guide dosing and scheduling for subsequent studies.
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How to Contact Us
At Creative Biolabs, we fully understand the importance of ADME studies in drug development and are dedicated to providing our clients with exceptional customer service and support. We are also exploring the most advanced technologies and methods to enhance our capabilities and provide our customers with effective ADME solutions.
Contact us now to learn more about our high-throughput ADME services and how we can support your drug development programs.
For Research Use Only | Not For Clinical Use
