CCL2-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP6, ΔΔICP34.5), hTERT-CCL2(Cat#: CyOV-0100XY)

This product is a CCL2 expressing oncolytic herpes simplex virus, which is based on HSV-1 with ICP6 and two copies of ICP34.5 deleted. ICP6 encodes a viral ribonucleotide reductase (vRR) function that allows replication of wild-type HSV to occur even in quiescent cells, such as the neurons. ICP34.5 protein, is important for viral replication, viral exit from infected cells, prevention of the premature shut-off of protein synthesis in the infected host, and neurovirulence. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.

Specifications

Family Herpesviridae
Species Herpes simplex virus
Serotype Herpes simplex virus 1
Backbone HSV-1 (ΔICP6, ΔΔICP34.5)
Backbone Background Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability.
Gene Modification ΔICP6, ΔΔICP34.5
Promoter hTERT
Transgene CCL2
Type of Transgene Cytokine
Related Target/Protein C-C motif chemokine ligand 2
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Glioma

Transgene

Alternative Names CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2
Gene ID 6347

Information

Introduction The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection.

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