hTNFα-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), CMV-hTNFα(Cat#: CyOV-0285XY)

This product is a hTNFα expressing oncolytic herpes simplex virus, which is based on HSV-2 with ICP10PK deleted. The herpes simplex virus type 2 (HSV-2) protein ICP10PK has anti-apoptotic activity independent of other viral proteins that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation. The deletion of ICP10PK can enhance the oncolytic activity. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.

Specifications

Family Herpesviridae
Species Herpes simplex virus
Serotype Herpes simplex virus 2
Backbone HSV-2 (ΔICP10PK)
Backbone Background Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability.
Gene Modification ΔICP10PK
Promoter CMV
Transgene hTNFα
Type of Transgene Cytokine
Related Target/Protein Tumor necrosis factor alpha
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Neurodegenerative diseases

Transgene

Alternative Names hTNFα, DIF-alpha, TNFA, TNFSF2, TNLG1F, TNF, tumor necrosis factor
Gene ID 7124

Information

Introduction Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons.

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