IL-18-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), SV40-IL-18(Cat#: CyOV-0390XY)
DatasheetThis product is a IL-18 expressing oncolytic herpes simplex virus, which is based on HSV-2 with RL deleted. The deletion lies entirely within the sequences deleted in JH2604 in which only 850 bp are removed from the RL. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔRL) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔRL |
| Promoter | SV40 |
| Transgene | IL-18 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 18 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Transgene | |
|---|---|
| Alternative Names | IGIF, IL-18, IL18, IL-1g, IL1F4, interleukin 18 |
| Gene ID | 3606 |
Information | |
|---|---|
| Introduction | Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. |
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