GM-CSF-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), pSE-GMCSF(Cat#: CyOV-0018WQ)

This product is a GM-CSF expressing oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.The GM-CSF is a monomeric glycoprotein that functions as a cytokine-it is a white blood cell growth factor.The deletion of E3L and GM-CSF expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔE3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L
Promoter pSE
Transgene GM-CSF
Type of Transgene Cytokine
Related Target/Protein Granulocyte-macrophage colony-stimulating factor
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Melanoma, Breast Cancer

Transgene

Alternative Names CSF2; GMCSF
Gene ID 100137216
UniProt ID P04141

Information

Introduction Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

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