mLIGHT-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSE-mLIGHT(Cat#: CyOV-0143WQ)

This product is a TNFSF14 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. The encoded protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. The deletion of K3L and TNFSF14 expressing could enhance the immune and anti-tumor activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications

Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter pSE
Transgene mLIGHT
Type of Transgene Cytokine
Related Target/Protein TNF superfamily member 14
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Tumor

Transgene

Alternative Names LTg; CD258; HVEML; LIGHT
Gene ID 8740
UniProt ID O43557

Information

Introduction The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported

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