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Oncolytic Viruses in Mesothelioma Treatment

Introduction of Mesothelioma

Mesothelioma is an uncommon malignancy of the parietal and visceral mesothelium. Malignant pleural mesothelioma (MPM) accounts for 90% of cases, as inhalation asbestos exposure is the major risk factor. Typical symptoms of MPM include shortness of breath, chest pain, and weight loss. Characteristic findings on chest imaging are pleural abnormalities, such as a unilateral effusion, calcified plaques, thickening, or masses. Diagnosis often needs a full-thickness pleural biopsy via pleuroscopy or video-assisted thoracoscopy.

Standard Therapy for Mesothelioma

The treatment of mesothelioma is to the extent possible multimodality strategy incorporating surgery, chemotherapy, and radiation. The initial step is evaluating whether the disease is surgically resectable. The two widely employed surgical techniques are extrapleural pneumonectomy (EPP) or the less radical pleurectomy/decortication (P/D), and the surgical approach is determined on a patient-specific basis. Chemotherapy for MPM is recommended for all patients undergoing active therapy, with cisplatin, carboplatin/pemetrexed. In patients not eligible for surgical resection, cisplatin/pemetrexed was shown to have a superior effect compared to cisplatin monotherapy. The addition of bevacizumab to cisplatin/pemetrexed may offer further benefit, increasing overall survival. The role of radiation therapy is less clear, with most studies evaluating its use in the postoperative setting to reduce the risk of local recurrence.

Oncolytic Viruses in Mesothelioma Treatment

Oncolytic Viral Therapy for Mesothelioma

Reference

  1. Pease, D.F.; Kratzke, R.A. Oncolytic viral therapy for mesothelioma. Frontiers in oncology. 2017, 7:179.

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