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Oncolytic Viruses in Rectal Cancer Treatment

Rectal and/or colon cancer is called colorectal cancer and is the fourth most common cancer in the United States. The two types of cancer are grouped because they have many characteristics and are treated similarly. About one-third of the 145,000 cases of colorectal cancer diagnosed each year are found in the rectum. Therapies for those with unresectable or recurrent disease are not considered curative at present. Recently, oncolytic virus therapy (OVT) is a new potential treatment option for rectal cancer.

About Rectal Cancer

The rectum is the last six inches of the large bowel, connecting the colon to the anus. Rectal cancer occurs when cells in the rectum mutate and lose control. The disease may also develop when growths called polyps on the inner wall of the rectum develop and become cancerous.

Rectal cancer. Fig.1 Rectal cancer.

OVT in Rectal Cancer

Oncolytic virus (OV) is a new therapeutic method that is being widely studied. These viruses selectively infect cancer cells, causing them to lyse, while healthy cells remain intact. So far, vaccinia viruses (VACVs) and reoviruses (RVs) have been studied as OVs, targeting colorectal cancer cells, which can effectively lyse cancer cells and cancer stem cells.

Usurpation of the Ras signaling pathway by RV. Fig.2 Usurpation of the Ras signaling pathway by RV. (Della, 2015)

Although there are still many obstacles to overcome, compared with the current treatment, this novel method is considered to be less active, more effective, and with the least side effects. Therefore, as a positive practice method, it will show a broad prospect in the future.

As a pioneer and undisputed global leader in the development of OVTs, Creative Biolabs is actively launching our OncoVirapy™ platform to accelerate the success of immunotherapy for rectal cancer.

Reference

  1. Della, D.; et al. Applications of oncolytic viruses for cure of colorectal cancer. Cancer Research Journal. 2015(3), 4: 76-93.

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