Dsred-encoding Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-Dsred(Cat#: RepOV-0133XY)

This product is a Dsred encoding oncolytic herpes simplex virus, which is based on HSV-2 with ICP10PK deleted. The herpes simplex virus type 2 (HSV-2) protein ICP10PK has anti-apoptotic activity independent of other viral proteins that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation. The deletion of ICP10PK can enhance the oncolytic activity. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.

Specifications

Family Herpesviridae
Species Herpes simplex virus
Serotype Herpes simplex virus 2
Backbone HSV-2 (ΔICP10PK)
Backbone Background Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability.
Gene Modification ΔICP10PK
Promoter hTERT
Transgene Dsred
Type of Transgene Reporter gene
Related Target/Protein Discosoma red fluorescent protein
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Neurodegenerative diseases

Transgene

Alternative Names DsRed, Discosoma red fluorescent protein
UniProt ID Q2WG74

Information

Introduction Red fluorescent protein (RFP) is a fluorophore that fluoresces red-orange when excited. Several variants have been developed using directed mutagenesis. The original was isolated from Discosoma, and named DsRed. Others are now available that fluoresce orange, red, and far-red.RFP is approximately 25.9 kDa. The excitation maximum is 558 nm, and the emission maximum is 583 nm.

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