lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), hTERT-lacZ(Cat#: RepOV-0052XY)
DatasheetThis product is a lacZ encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP0 deleted. The deletion of ICP0 were attenuated for viral growth, and impaired for viral reactivation when equivalent latent infections were established in vivo. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 1 |
| Backbone | HSV-1 (ΔΔICP0) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔΔICP0 |
| Promoter | hTERT |
| Transgene | lacZ |
| Type of Transgene | Reporter gene |
| Related Target/Protein | Beta-galactosidase |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Osteosarcoma |
Transgene | |
|---|---|
| Alternative Names | lacZ, b0344, ECK0341, beta-galactosidase |
| Gene ID | 945006 |
| UniProt ID | P00722 |
Information | |
|---|---|
| Introduction | The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. The gene product of lacZ is β-galactosidase which cleaves lactose, a disaccharide, into glucose and galactose. |
Customer Reviews and Q&As |
|---|
|
There are currently no customer reviews or questions for lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), hTERT-lacZ (RepOV-0052XY). Click the button below to contact us or submit your feedback about this product. |
All products and services are for Research Use Only. Not For Clinical Use.
Other products
- IL-2-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), hTERT-IL-2 (CAT#: CyOV-0097XY)
- IL-10-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), SV40-IL-10 (CAT#: CyOV-0387XY)
- MMP9-expressing Oncolytic Herpes Simplex Virus 1 (ΔICP27), CMV-MMP9 (CAT#: CyOV-0007XY)
- EGFP-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP6, ΔΔICP34.5), SV40-EGFP (CAT#: RepOV-0104XY)
- mCherry-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP6, ΔΔICP34.5), SV40-mCherry (CAT#: RepOV-0108XY)
- MMP9-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), IE4/5-MMP9 (CAT#: CyOV-0189XY)
- IL-18-expressing Oncolytic Herpes Simplex Virus 2 (ΔRL), hTERT-IL-18 (CAT#: CyOV-0334XY)
- CCL2-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), SV40-CCL2 (CAT#: CyOV-0268XY)
PRODUCTS
Online Inquiry