Reporter-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L,ΔK3), pSL-(lacZ) (RepOV-0088WQ)
DatasheetThis product is a lacZ encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L and K3L double deleted.Protein E3 plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities. Protein K3 acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff.The double deletion of E3L and K3L with oncolytic-rendered modifications could enhance an immune response to a poxvirus vaccine.This product can be used in oncolytic virotherapy research and vaccinie application.
| Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔE3L,ΔK3) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔE3L,ΔK3 |
| Promoter | pSL |
| Transgene | lacZ |
| Type of Transgene | Reporter gene |
| Related Target/Protein | Beta-galactosidase |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine |
| Transgene | |
|---|---|
| Alternative Names | lacZ, b0344, ECK0341, beta-galactosidase |
| Gene ID | 945006 |
| Information | |
|---|---|
| Introduction | The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. The gene product of lacZ is β-galactosidase which cleaves lactose, a disaccharide, into glucose and galactose. |
All services and products are for lab research only, not for any clinical use.
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