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Alanyl-tRNA synthetase

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The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAART-LX259 Anti-Alanyl-tRNA synthetase (M6-P2E5) h(CD28-CD3ζ) CAART, pCDCAAR1 Human M6-P2E5 Mouse scFv-CD28-CD3ζ Lentiviral vector B cell   Add to Cart   Datasheet
CAART-LX260 Anti-Alanyl-tRNA synthetase (M6-P2E5) h(4-1BB-CD3ζ) CAART, pCDCAAR1 Human M6-P2E5 Mouse scFv-4-1BB-CD3ζ Lentiviral vector B cell   Add to Cart   Datasheet
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