CellRapeutics™ In Vivo Cell Engineering Development Solutions

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The Overview of In Vivo Cell Engineering Services

Gene therapy using ex vivo transduction of patient-derived cells has demonstrated great efficiency in the treatment of immunodeficiencies and cancers. However, this approach is costly, technically challenging, and not easily scalable to large patient groups. Furthermore, manipulating cells outside the body may result in unfavorable phenotypic alterations. Direct in vivo cell therapy would eliminate these concerns and has been proven to be safe and effective in clinical studies for illnesses. Therefore, developing in vivo cell engineering services will promote breakthroughs in in vivo cell therapy.

Fig.1 Advantages of in vivo CAR-T therapy. (Xin, et al., 2022) Fig.1 In vivo CAR-T cell overcomes many difficults faced by comventional CAR-T.¹

Our CellRapeutics™ In Vivo Cell Engineering Development Services

Leveraging long experience in cell engineering, Creative Biolabs succeed in establishing a wide range of safe and effective CellRapeutics™ in vivo cell engineering development services to support sciences research in immunology and related biomedical industries. Our CellRapeutics™ in vivo cell engineering development services incorporate novel technologies such as CRISPR/Cas9 to integrate the vectors (viral and non-viral) and the encoded gene, then transfect the integrated vectors into the body, which aims to modify immune cells in situ. We provide comprehensive customized optimized services covering vectors construction to function verification so as to meet global customers' diverse demands.

The followings are parts of our CellRapeutics™ in vivo cell engineering development services.

In Vivo CAR-T Cell Engineering Services

Creative Biolabs provides comprehensive in vivo CAR-T cell engineering services to support global customers' CAR-T projects.

Fig.2 Generating CAR-T in vivo. (Xin, et al., 2022)

In Vivo B Cell Engineering Service

Creative Biolabs provides one-stop in vivo B cell engineering services to assist global customers' B cell engineering research.

Fig.3 B cell engineering. (Sun, et al., 2023)

In Vivo CAR-NK Cell Engineering Service

Creative Biolabs provides customized in vivo CAR-NK cell engineering services to meet global clients' various needs.

Fig.4 The constructs and targets of CAR-NK cells. (Zhang, et al., 2022)

In Vivo CAR-M Cell Engineering Service

Creative Biolabs provides customized in vivo CAR-M cell engineering services to speed up customers' CAR-M development.

Fig.5 In vivo CAR-M cells. (Hadiloo, et al., 2023)
Fig.5 In vivo manufacturing of CAR M cells.⁴

Advantages of Our CellRapeutics™ In Vivo Cell Engineering Development Services

Work with Creative Biolabs

If you are interested in our CellRapeutics™ in vivo cell engineering development services, please contact us with no hesitation. We are sincerely looking forward to working with global customers.

References

Xin, Tianqing, et al. "In-vivo induced CAR-T cell for the potential breakthrough to overcome the barriers of current CAR-T cell therapy." Frontiers in Oncology 12 (2022): 809754.
Sun, Caijun, Teng Zuo, and Ziyu Wen. "B cell engineering in vivo: Accelerating induction of broadly neutralizing antibodies against HIV-1 infection." Signal Transduction and Targeted Therapy 8.1 (2023): 13.
Zhang, Leisheng, et al. "CAR-NK cells for cancer immunotherapy: from bench to bedside." Biomarker Research 10.1 (2022): 12.
Hadiloo, Kaveh, et al. "The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors." Biomarker Research 11.1 (2023): 103.