As a global contract research organization, Creative Biolabs established one-stop CAR-T cell therapy development solutions to advance your CAR-T cell product candidate. We offer comprehensive solutions distinctly for the progressive biopharma venture. To build more powerful CAR-T cells, we have developed TRAC-CAR T cell with CRISPR/Cas9 technology.
Challenges for Conventional CAR-T Cell
CAR-T cell therapy has shown significant efficacy in the treatment of acute leukemia and non-hodgkin lymphoma, etc., thus considering to be one of the most promising cancer immunotherapies. While some existing disadvantages need to be improved for making more efficient CAR-T cells.
For conventional CAR-T cells, CAR genes are transferred into the T cell genome by retroviruses or lentiviruses. They can cause CAR genes to be randomly inserted into the locus of genome which may elicit potential genetic side effects.
RNA-guided DNA targeting technology, is triggering a revolution in the field of biology. CRISPR/Cas9 has demonstrated great potential for precise genetic manipulation. CRISPR/Cas9 has significantly hit the headlines as a powerful tool that is dramatically changing the way scientists are advancing researches. CRISPR technology can deliver a CAR gene to a very specific location (TRAC) in the genome of the T cell. This precise approach resulted in CAR T cells with more stamina.
Advantages of CRISPR/Cas9 Technology
TRAC-CAR-T Cell Development Services
Fig.1 RISPR/Cas9-targeted CAR gene integration into the TRAC locus. (Eyquemc, 2017) Utilizing the CRISPR/Cas9 technology that holds great promise as an efficient gene knock-in platform, we have developed end-to-end CRISPR/Cas9 services to directing the specific CARs to the T-cell receptor α constant (TRAC) locus (see Fig.1). Compared with conventional CAR T cells, TRAC-CAR T cells exhibit uniform CAR expression which results in enhanced T cell potency and safety profile. Our TRAC-CAR T platform will advance your desired immunotherapies through CRISPR/Cas9 genome editing which is more precise. Leverage the CRISPR to build CAR T cells, the genomic engines will run more smoothly, which means TRAC-CAR T cells rack up more trouble-free miles with long-distance races.
CRISPR/Cas9 Service Process
Leverage the expertise of our experienced scientists to expedite and innovate your therapeutic CAR-T projects, we are inspired by NR4A target and are dedicated to providing NR4A knock out CAR-T cell development services.
TRAC-CAR-T Cell Advantages
To accelerate your CAR-T project, develop engineered T cell with precise CAR insertion, Creative Biolabs offers an end-to-end CRISPR/Cas9 solution that holds immense promise for advancing immunotherapy. We combine the traditional and the most advanced CRISPR/Cas9 genetic manipulation technology to efficiently produce more powerful CAR-T cells addressing urgent unmet medical demands. Please feel free to contact us to learn how we can be involved in your project.
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