Adoptive T cell therapy using T cell receptor (TCR) engineered T cells is an attractive cancer treatment strategy. The success of this therapy depends on the functional affinity of the transduced TCR for targeting tumor antigens. Unlike CAR T cells that recognize proteins expressed on the surface, TCRs can recognize tumor-specific proteins on the inside of cells. Altering the specificity of TCR is one of the popular strategies for genetic modification of T cells to enhance the killing activity of T cells. As the leading cell therapeutics biotech that provides cell therapy related services, Creative Biolabs masters the most advanced technology and has a very rich extensive experience and thus, is able to offer the best TCR vector products and TCR design & construction services.
Specifically, Creative Biolabs has designed and developed a comprehensive list of TCR vector products targeting neo-antigens which would be promising targets for the engineered TCR-T cell therapy. With high-affinity TCR technology, Creative Biolabs can identify candidate target tumor antigens and tumor-specific TCR sequences to create TCR vector products.
In addition to designing and cloning TCR vectors, we have a highly qualified team and advanced technology to perform TCR engineering services, covering every unit of manufacturing and delivery pipeline. Through the construction of engineering TCR and a series of measurements, such as transgene expression, TCR/CD3 stability, lymphocyte antigen reactivity and cytotoxicity, animal experiments, etc., we provide cGMP-compliant TCR products for preclinical and clinical trials.
Fig.1 TCR structure.
Please browse the target below to find the right product for you.
Associated Antigen Target
All services and products are only for lab research use, not for any clinical diagnosis or treatment.
Nanoparticle Tiny Tech for Programming T Cells: A novel technology to increase the efficiency and value of your CAR-T therapy project.LEARN MORE
Angiotensin-converting Enzyme 2 (ACE2)-CHO Cell Line Model for COVID-19: Helps researchers to further study the interaction between the receptor ACE2 and the COVID-19 virus.LEARN MORE
TRAC-CAR-T Cell Development with CRISPR/Cas9 Technology: A novel technology to build more powerful CAR-T cells.LEARN MORE