Get a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MOREWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MOREUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don’t find the answers you’re looking for, contact us for additional assistance.
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Adoptive T cell therapy using T cell receptor (TCR) engineered T cells is an attractive cancer treatment strategy. The success of this therapy depends on the functional affinity of the transduced TCR for targeting tumor antigens. Unlike CAR T cells that recognize proteins expressed on the surface, TCRs can recognize tumor-specific proteins on the inside of cells. Altering the specificity of TCR is one of the popular strategies for genetic modification of T cells to enhance the killing activity of T cells. As the leading cell therapeutics biotech that provides cell therapy related services, Creative Biolabs masters the most advanced technology and has a very rich extensive experience and thus, is able to offer the best TCR vector products and TCR design & construction services.
Specifically, Creative Biolabs has designed and developed a comprehensive list of TCR vector products targeting neo-antigens which would be promising targets for the engineered TCR-T cell therapy. With high-affinity TCR technology, Creative Biolabs can identify candidate target tumor antigens and tumor-specific TCR sequences to create TCR vector products.
In addition to designing and cloning TCR vectors, we have a highly qualified team and advanced technology to perform TCR engineering services, covering every unit of manufacturing and delivery pipeline. Through the construction of engineering TCR and a series of measurements, such as transgene expression, TCR/CD3 stability, lymphocyte antigen reactivity and cytotoxicity, animal experiments, etc., we provide cGMP-compliant TCR products for preclinical and clinical trials.
Fig.1 TCR structure.
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All services and products are only for lab research use, not for any clinical diagnosis or treatment.
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