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Supported by in-house scientists and first-in-class technical platform, Creative Biolabs is confident in providing an integrated solution for mouse H2 genotyping service, including available methods for sample preprocessing and H2 genotyping. Creative Biolabs has developed several methods for H2 genotyping from a wide of sources.
The H2 complex, as the major histocompatibility complex (MHC) of the mouse, is located on chromosome 17. It contains several genes critical to the function of the immune system and plays an important role in immune response. There are two major classes of genes, I and II, involved in the immune response, which are both structurally and functionally different. Class I genes code for single-chain proteins of approximately 44 kDa and are highly polymorphic. These molecules are glycosylated and expressed on the surface of all nucleated cells in the body associated with a smaller 12-kDa protein (named β2-microglobulin). Class II genes code for proteins comprised of two types, α, and β, which are separately encoded. The class II H2 molecules present fragments of molecules (usually proteins) to the CD4+ subset of T lymphocytes.
Fig.1 (Left) Genomic map of the protein coding MHC loci among the H2 regions. (Shiina T, 2016)
Fig.2 (Right) H2 class I and II molecules on the cell surface. (Stuart P, 2015)
The advancement in mouse genotyping approaches makes the H2 genotyping accessible. Creative Biolabs has developed a dedicated NGS-based H2 genotyping service to meet your program requirements. We are committed to providing more comprehensive and targeted accurate genotyping analysis results and facilitating scientific research. Our scientists and technicians are experienced in every step with high dedication to ensuring accurate outcomes.
Fig.3 Flow diagram of H2 genotyping.
Creative Biolabs' scientists are dedicated to bringing together years of valuable experience to help our clients shorten the clinical study journey. We are committed to the H2 genotyping service and dedicated to reducing the overall project development timeline for our clients. For further details, please don't hesitate to contact us and see how we can help you reach your clinical vision.
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