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Gamma Delta (γδ) T Cell Platform

Gamma Delta (γδ) T Cell Platform

Gamma delta (γδ) T cells present the next generation of effector cells for immunotherapy. Unlike alpha beta (αβ) T cell therapies, γδ T cells can be administered off-the-shelf and no need for tailored one for each individual, allowing for scaling up manufacturing process and broader potential use. Accelerating the development of γδ T cell therapies is to deliver the cell therapies of the future. Equipped with rich experience, profound expertise, and state-of-the-art technology, Creative Biolabs has established a cutting-edge γδ T cell platform to provide highly effective off the shelf Vδ1 T cells and Vδ2 T cells with the potential to offer help in the treatment of cancers. We also offer a full range of high-quality services, including γδ T cell isolation, γδ T cell activation, γδ T cell expansion, γδ T cell characterization, and γδ T cell engineering services, to generate Vδ T cell populations suitable for our clients' γδ T cell research and project development. Through our proven quality system, clients could accelerate their research with the most comprehensive view of γδ T cells.

Custom Gamma Delta (γδ) T cell Development at Creative Biolabs

Gamma Delta (γδ) T Cell Platform

With years of research in γδ T cell development, Creative Biolabs has established a cutting-edge γδ T cell platform for selective isolation, activation, expansion, and characterization of Vδ1 and Vδ2 populations from human tissues and blood. We have developed an economical method to achieve large-scale ex vivo expansion of these γδ T cells. Moreover, our scientists have gained significant knowledge to understand the bioactivity and the activation modalities of γδT cells. We also offer custom γδ T cell engineering services with antibody or cell-based strategies for high efficacy and improved safety. Besides, our R&D scientific team has successfully designed and developed γδ bispecific T-cell engagers, which has demonstrated improved safety and efficacy compared to conventional bispecific T-cell engagers. Creative Biolabs has perfected our technical pipelines in the development of γδ bispecific T-cell engagers. We would like to share our knowledge and passion in this field to facilitate our customers' research and project development.

Gamma Delta (γδ) T Cell Platform

This subset of γδ T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. We believe that future clinical trials would explore the use of γδ T cells or the combinatorial use with other therapeutic agents, such as chimeric antigen receptor (CAR) and immune checkpoint inhibitors. Creative Biolabs strives to constantly improve the quality of the expanded γδ T cells and offer the most comprehensive γδ T cell engineering services. We are proud to provide optional tools to facilitate our clients' research in anti-tumor immunotherapy. For more detailed information, please feel free to contact us or directly send us an inquiry.

References

  1. Yazdanifar, M.; et al. γδ T Cells: The ideal tool for cancer immunotherapy. Cells. 2020, 9(5): 1305.
  2. Tan, W.K.; et al. Expansion of gamma delta T cells-A short review on bisphosphonate and K562-based methods. 2018.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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