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TCR Generation & Optimization

To increase efficiencies and accelerate the drug discovery and development process, Creative Biolabs offers a broad range of early development services, especially for TCR engineered T cell design, construct, validation, and function assessment. Particularly, the generation and optimization of TCR is the key step of TCR development, which can be specially tailored to your project. Creative Biolabs can offer you several creative approaches to generate TCRs that are specific for the antigens that are expressed by a wider variety of tumor cell types to meet your special needs and also has optimized strategies to increase TCR affinity.

TCR Generation & Optimization Platform

1. TCR Generation
2. TCR Optimization
3. TCR Characterization
TCR Generated from patient's TIL TCR Generated from Phage Display TCR Generated from In Vivo System   TCR Affinity Optimization TCR Affinity Maturation  
  1. TCR Generation

    2. Based on the outstanding expertise and rich experience, Creative Biolabs has specially developed a system approach of TCR generation for TCR development. Particularly, we offer our clients a special pipeline of antigen-specific TCR-T cell generation in terms of the method of direct targeting of human tumors using autologous TILs to meet your needs. We also provide TCRs generated from phage display. The phage surface display is an effective technology optimized by our expert team, which will be signally promoting the ability of recognition to tumor antigen. In addition, TCR transgenic model is developed by Creative Biolabs to determine the magnitude of T cell tolerance to tumor-associated antigen. T cells are incubated with tumor cells from the patient and TCR genes are cloned from T cells that react to the tumor cells so that high-affinity TCRs for the target antigen are generated.

  2. TCR Optimization

    3. Altering the specificity of T cell receptor (TCR) is one of the most popular strategies for genetically modifying T cells to enhance the tumor-killing activity of T cells. Creative Biolabs offers you three classics strategies to solve the problems, including TCR-C Murinization, Incorporation of Additional Cysteine Residue, and Increasing Avidity.

To obtain higher TCR affinity mature level for many efficient results in further research, we have successfully operated a platform for affinity maturation service, which can especially be used for TCR. Some vital methods/steps are as follows:

  • Untargeted Mutagenesis
  • Oligonucleotide-directed Mutagenesis
  • Phage Display Antibody Library Screening
  • Antibody Affinity Measurement
  • Peptide Affinity Maturation

For further details, please don't hesitate to contact us.

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