TCR Generation & Optimization

To increase efficiencies and accelerate the drug discovery and development process, Creative Biolabs offers a broad range of early development service, especially for TCR engineered T cell design, construct, validation and function assessment. Particularly, the generation and optimization of TCR is the key step of TCR development, which can be specially tailored to your project.

T cells are playing a significant role in immune system. The abilities of T cells to coordinate immunity and to deliver lethal hits against disease cells can be directed towards tumors by genetically modifying T cells. Genes encoding specific antigen receptors can be inserted to enable them to recognize and respond to cancer cells. However, tumor cells evolve to escape immunity, by using seemingly ingenious strategies of evasion and by subverting normal immune processes. Thus, tumors may down regulate antigen presentation through reduced antigen presentation through reduced antigen processing or MHC expression to effectively render T cells ‘blind’ to their presence.

Therefore, Creative Biolabs offers our clients two advanced services of T cells that are reactive against tumors and can be generated using genetic engineering, which involves inserting into the T cells genes encoding cell surface receptors that are able to detect TAAs. The services are one-stop CAR-T therapy development service and one-stop TCR engineered T cell development service, which are optimized by our high qualified groups with advanced technologies and rich experience. The process of one-stop TCR engineered T cell development service are TCR biomarker identification & selection, TCR generation & optimization, design & construction, TCR gene packaging & delivery, TCR in vitro assay, TCR-T preclinical in vivo test and TCR clinical trial. Creative Biolabs can offer you several creative approaches to generate TCRs that are specific for the antigens that are expressed by a wider variety of tumor cell types to meet your special needs and also have optimized strategies to increase TCR affinity.

Creative Biolabs has the capability to enable you to free up your time for core work and project. Our service can be designed to meet your special needs if you have any requirements. If you are interested in our service, please contact us by e-mail and our team will get back to you as soon as possible.

TCR biomarker identification & selection TCR generation & optimization TCR design & construction TCR gene packaging & delivery TCR-T in vitro assay TCR-T preclinical in vivo assay TCR-T clinical applications

Reference

1. Michaela H. Kershaw, et al. Gene-engineered T cells for cancer therapy. Cancer. 2013 Aug, 13: 535-541.