Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Equipped with state-of-the-art facilities and experienced immunology experts, Creative Biolabs is dedicated to providing high-quality GPLA genotyping services for our global clients.
The guinea pig MHC or guinea pig leucocyte antigen complex (GPLA) has been reported since 1973 and is classified into two classes. Class I antigens (BI, BL B3, or B4), these ubiquitous antigens correspond to mouse H2-D and H2-K antigens or to human HLA-A or HLA-B antigens. Class II and associated antigens (Ia), which have been defined as seven specificities (1, 2, 3, 4, 5, 6, 7). The GPLA antigens have a wide tissue distribution and are found on both lymphoid and nonlymphoid cells. In addition, class I and class II antigens are also present on some tumor cells including the L2C-N Leukemia. It was reported that, unlike mice or humans, most normally resting guinea pig T cells and most thymocytes have been reported to express Ia antigens. Class II antigens have also been described on several glandular epithelial cells, including guinea pig mammary gland cells.
With the advancement of genotyping approaches, GPLA genotyping has become accessible. Creative Biolabs has developed a dedicated NGS-based GPLA genotyping service to meet your program requirements. We are committed to providing more comprehensive and targeted accurate genotyping analysis results and facilitating scientific research. Our scientists and technicians are experienced in every step with high dedication to ensuring accurate outcomes.
Fig.1 Flow diagram of GPLA genotyping.
Creative Biolabs' scientists are dedicated to bringing together years of valuable experience to help our clients shorten the clinical study journey. We are committed to reducing the overall project development timeline for our clients. For further details, please don't hesitate to contact us and see how we can help you reach your clinical vision.
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