Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
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Creative Biolabs provides T cell receptor (TCR) products ranging from clinical diagnostics to therapeutic development, which expands the capabilities of TCR technology platform to clinical studies.
T lymphocytes, also known as T cells, recognize foreign antigen through the T cell receptors (TCRs). There are two types of TCRs that has been identified on the surface of T cells, the alpha/beta-TCR and the gamma/delta.-TCR, and the former one is expressed on the majority of T cells that recognize foreign antigens complexed with major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells. Throughout T-cell development and proliferation, the progeny of a single T cell will express the identical TCR and contain the identical TCR gene rearrangement that serves as a molecular marker of clonality, which is a complex and highly regulated process and any dysregulation may lead to disease, such as cancers, immunodeficiency and autoimmunity diseases. Therefore, clonality assay via assessment of TCR gene rearrangements has become a critical and valuable tool in the diagnostic of lympho-proliferations and T cell related diseases. Creative Biolabs uses diversiform methods including Southern blot, PCR, and flow cytometry to analyze TCR gene rearrangements for clinical diagnostics program. Our multidisciplinary diagnostic platform guarantees that we can provide the most reliable data to accelerate your project process.
Recently, strategy to genetically modify T cells through altering the specificity of the TCR has shown great potential in treating plenty of diseases, especially tumors, which is also called as TCR gene transfer therapy. With deep understanding of this burgeoning immunotherapy and years experience in gene engineering field, Creative Biolabs now provides an unparalleled TCR construction platform to perform typical TCR construction, T cell modification and TCR products validation services. The high-affinity TCR products can be applied for immunotherapy of various malignancies, autoimmune diseases and immunodeficiency. In TCR gene transfer therapy, although the interaction between peptide and TCR is limited to a certain MHC type, the most important advantage is the peptide antigen can also derive from the cell inside. Creative Biolabs has developed a variety of TCR products covering a broad range of immune-mediated diseases associated antigens respectively.
With the availability of profound TCR knowledge, certified technical staff and numerous state-of-the-art instruments, Creative Biolabs is capable of offering the best TCRs related products and services to satisfy your specific needs.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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