CAR Vector Products

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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Our advanced CAR vector products help you accelerate immunotherapy development, obtain high-quality gene delivery systems, and develop highly specific and potent CAR constructs through comprehensive design, synthesis, and packaging capabilities.

Introduction

Chimeric antigen receptor (CAR)-T cell therapy represents a paradigm shift in cancer treatment, demonstrating unprecedented success, particularly in relapsed/refractory hematological malignancies. The efficacy of CAR-T therapy, however, is deeply rooted in the design and quality of the CAR vector, which dictates CAR expression, T cell function, and safety. Continuous advancements in CAR design, from basic first-generation constructs to sophisticated fourth-generation "TRUCKs" with enhanced functionality and safety switches, are crucial for overcoming challenges like antigen escape and toxicity, paving the way for broader clinical application.

Fig.1 Four generations of CAR constructs. (OA Literature). Fig.1 CAR design evolution.¹

CAR Vector Products at Creative Biolabs

At Creative Biolabs, our CAR vector products are meticulously designed to empower your research in the dynamic field of cell therapeutics. We provide a complete suite of solutions for developing and delivering advanced CAR constructs, ensuring your engineered immune cells achieve optimal therapeutic potential in preclinical settings. Our offerings enable precise targeting of various cancer antigens, enhanced CAR-T cell persistence and function, and the integration of sophisticated safety mechanisms, addressing critical challenges in cancer immunotherapy research. Whether you require standard CAR designs or highly customized configurations, our products and services provide the robust foundation necessary to push the boundaries of your projects.

CAR Vector Types

The type of immune cell engineered

Standard scFv - CD3ζ backbone.
Applied in autologous/allogeneic formats.

The type of CAR vector. (Creative Biolabs Original)

Structural and functional specificity

Modular control, multi-antigen targeting, novel signaling adaptations.

The type of CAR vector. (Creative Biolabs Original)

TCR-Like CAR Vectors

Non-Regular CAR Vectors

Dual CAR Vectors

TriCAR Vectors

Service Process

The workflow of CAR vector production. (Creative Biolabs Original)

Key Advantages

The key advantages of CAR vector production. (Creative Biolabs Original)

One-stop Solution for CAR Vector Development

Cutting-Edge CAR Design Expertise

Accelerated Research Timelines

FAQs

Q1: How can Creative Biolabs' CAR vector products help me overcome antigen escape in my cancer models?

A1: Our diverse range of CAR vector products, especially our multi-targeted and innovative non-standard CAR vectors like universal CARs and switch CARs, are specifically designed to address antigen escape by targeting multiple antigens or allowing for flexible target switching.

Q2: What are the primary advantages of using Creative Biolabs' fourth-generation CAR vectors compared to earlier generations?

A2: Our fourth-generation CAR vectors are engineered with inducible expression units for cytokines. This allows for regulated immune cell activation and overcomes "target, off-tumor" defects, enhancing anti-tumor efficacy while potentially reducing systemic toxicities, providing a more refined and potent tool for your research.

Q3: Can Creative Biolabs assist if my project requires a CAR construct for a non-T cell type, such as NK cells or B cells?

A3: Absolutely! We offer specialized CAR-NK Vectors and CAR-B Vectors, as well as CAR-MA Vectors. Our expertise extends to engineering various immune cell types, providing you with the tailored tools needed for your specific cell therapy platform.

Related Services

To ensure the success of your CAR-T cell therapy research and development, Creative Biolabs offers a suite of complementary services designed to support you at every stage:

CAR Design & Construction

Beyond our proficiency in crafting and developing conventional scFv-based CARs, we provide a wide range of cutting-edge CAR vector offerings, such as TanCAR, Universal CAR, VHH-based CAR, and Switch CAR, to name a few.

CAR-T gene packaging and delivery

To simplify your research initiatives, our researchers utilize flexible methods for delivering CAR constructs into T cells - viral transfection approaches, for instance - to smooth the progress of your projects.

We encourage you to reach out to us for a discussion on your specific needs.

Why Choose Us?

Creative Biolabs is your trusted partner for advancing CAR-based cell therapies. Our comprehensive portfolio of CAR vector products, combined with our unparalleled expertise in custom design, high-quality production, and robust validation, positions us uniquely to support your groundbreaking research. We are dedicated to providing cutting-edge solutions that empower scientists to unlock the full potential of engineered immune cells against cancer.

Feel free to contact us to discover a tailored solution that fits your requirements.

Reference

Zhang, Xiaomin et al. "CAR-T Cell Therapy in Hematological Malignancies: Current Opportunities and Challenges." Frontiers in immunology vol. 13 927153. 10 Jun. 2022, https://doi.org/10.3389/fimmu.2022.927153. Distributed under Open Access License CC BY 4.0, without modification.

CAR-T Vector Products

CAR-MA Vector Products

TCR-Like CAR Vector Products