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CAR Vector Products

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Since the conventional cornerstones of cancer treatment (surgery, chemotherapy and radiation therapy) show more and more limitations for a variety of human malignancies, genetic engineering of the immune system has shown great promise in the treatment of cancer, especially the use of chimeric antigen receptor (CAR)-T cells. As the leading cell therapeutics biotech that provides CAR-T cell therapy related services, Creative Biolabs masters the most advanced technology and has a very rich extensive experience and thus, can offer the best CAR vector products and CAR design & construction services.

In general, Creative Biolabs provides four generations of CAR products. The first-generation CAR composed of basic elements has been widely used in clinical trials of early cancer immunotherapy. Unlike the first generation with an intracellular signaling domain (such as CD3ζ or FcεRIγ), our second-generation CAR consists of an activation domain and a costimulatory signaling domain (such as CD28 or 4-1BB), whose structure can support longer Time anti-tumor effect. Similar to this strategy, two different costimulatory signal regions were constructed in the third-generation CAR to promote T cell activation signals and significantly enhance CAR-T cell proliferation and survival. Besides, the fourth-generation CAR construct has been engineered with inducible expression units (such as cytokines (such as IL-12)). This inducible transgenic cytokine gene can effectively overcome the "target, off-tumor" defect.

CAR design evolution.

Fig.1 CAR design evolution.

CAR Vector Types

In addition to our expertise in designing and generating traditional scFv-based CARs, we offer a diverse selection of innovative CAR vector products, including TanCAR, Universal CAR, VHH-based CAR, and Switch CAR, among others. For a comprehensive range of specialized CARs, please visit CAR Design & Construction to discover the product that aligns with your interests.

To streamline your project, we also provide CAR-T gene packaging and delivery services. Our scientists employ adaptable techniques for introducing CAR constructs into T cells, such as viral transfection methods.

With our extensive array of CAR-T gene transfection strategies, we extend CAR-T cell production services to meet your specific needs, whether for standard CAR-T cells or unconventional CAR-T cells. Moreover, we offer highly tailored CAR-T production services to accommodate your unique requirements.

Customization for Specific Needs

Every cancer type presents a unique challenge. Creative Biolabs provides customization services for CAR vectors tailored to specific cancer indications, ensuring optimal therapeutic efficacy. Don't hesitate to contact us to find a customized solution that suits your needs.

Please browse the target below to find the right product for you.

We have developed a proprietary online system for customizing CAR and CAR cell products, which offers full options to meet all unique needs, including but not limited to conventional or unconventional CAR constructs, as well as a variety of vectors and cells. The customization process can be completed with just a few simple clicks, please feel free to try it out.
customizing CAR and CAR cell products
TCR-Like CAR Vector Products
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