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One-stop Cytokine Release Syndrome (CRS) Management Solutions

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

One-stop Cytokine Release Syndrome (CRS) Management Solutions

One of the most prominent toxicities associated with CAR-T immunotherapies is cytokine-release syndrome (CRS), which can be fatal if not properly identified and managed. Creative Biolabs offers the most extensive portfolio of CRS immunoassay platforms and services for measuring CRS-associated inflammatory cytokines and evaluating CRS process. Whether you need qualitative or quantitative results, have limited sample, require single or multianalyte analysis, you will be able to find an optimal solution from Creative Biolabs.

Our Service Portfolio

By CRS Research Area

Cytokine release syndrome (CRS) is a collection of acute systemic inflammatory syndromes associated with certain types of immunotherapy (especially immunotherapy involving T cells). The syndrome is characterized by fever and multiple organ dysfunction when immune cells are activated and release large amounts of cytokines into the body. Creative Biolabs gave a comprehensive overview of CRS, mainly providing CRS management solutions for the following diseases:

By CRS Assay Type

Creative Biolabs provide one-stop assay portfolio for CRS cytokine release assay, cytotoxicity analysis in vitro and in vivo. Multiple methods are available for cytokine release assay, including Intracellular Cytokine Staining (ICS), ELISPOT and ELISA / CBA. Multiple combination of cytokine panels is also ready for cytokine release assay. In addition, we also provide comprehensive in vitro and in vivo CRS research models supporting CRS assay, such as in vitro human PBMCs and NHP PBMCs models, PBMC-engrafted humanized in vivo mouse model, and donor-dependent in vivo mouse model.

CRS Research Models includes In Vitro CRS Models and In Vivo CRS Models

By CRS Progression

The occurrence and evolution of CRS involve several events, including early CAR-T cell expansion and extended immune response, early identification and diagnosis of CRS, determinant of CRS, toxicity assessment of CRS, and specific treatment development.

  • CRS Monitoring Service
  • CRS Early Identification/Diagnosis Service
  • CRS Grading Toxicity Assessment Service
  • CRS Treatment Development Service

Highlighted CRS Technology Platform

To thoroughly investigate mechanism of action of your agent, we have developed several novel platforms for fully understand the therapeutic effect, immunogenicity, and candidate biomarkers induced by your agent in vitro and in vivo.

If you are interested in our services, please send an email to contact us, and our team will get back to you as soon as possible.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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