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One-stop TCR-NK Therapy Development

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Natural killer (NK) cells have broad prospects in tumor immunotherapy due to their unique biological functions and characteristics. The introduction of chimeric antigen receptors into NK cells has been the main practical method to target NK cells to specific surface antigens so far. In contrast, T cell receptors (TCR) can recognize all cellular proteins and can provide a large number of cytotoxic T lymphocytes (CTL).

To expand its recognition ability, NK cells equipped with TCR gene delivery stand out as a novel tool in the field of adoptive immunotherapy, which can also overcome the main obstacle of "pairing error" in TCR gene therapy. At Creative Biolabs, we provide one-stop service for TCR-NK therapy development, ranging from TCR construct design and optimization, TCR virus particle packaging, TCR-NKT cell engineering, to preclinical and clinical evaluation of TCR-NK cells. We are dedicated to providing high-quality customized service to best meet your research needs, turnaround time, and budget requirements.

Advantages of NK cells and TCR guided natural killer cells (TCR-NK)

NK cells are the most effective cancer killer in the human body, and they can exert their effector functions without pre-stimulation. They are also not expected to express the cytokines that cause the cytokine release syndrome. Another important feature is that NK cells from one donor can be safely administered to other patients without causing graft-versus-host disease (GvHD). This provides the possibility of mass production of non-personalized cell therapy products, which can be produced in advance and can be provided on demand in an "off-the-shelf" manner.

At Creative Biolabs, we combine a wide range of TCR targets with the efficacy of allogeneic NK cells to produce transformative TCR-NK products for the treatment of solid cancers. We have a unique proprietary technology platform that involves engineered NK cells to express the selected TCR together with CD3, and CD3 constitutes a key element of signal transduction through TCR.

One-stop TCR-NK Therapy Development

One-stop TCR-NK Therapy Development

As the leading cell therapeutics biotech that provides cell therapy related services, Creative Biolabs provides one-stop services for TCR-NK therapy development, including but not limited to:

If you are interested in our services, please send an email to contact us, and our team will get back to you as soon as possible.

Reference

  1. Shissler, S. C., et al. (2017). Mixed signals: co-stimulation in invariant natural killer T cell-mediated cancer immunotherapy. Frontiers in immunology, 8, 1447.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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