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CD40

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This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-ZP7101 Anti-CD40 (PPAT-071-11) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human PPAT-071-11 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7102 Anti-CD40 (3B6) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3B6 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7103 Anti-CD40 (3B6) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 3B6 Rabbit scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7104 Anti-CD40 (6H6) h(CD28-CD3ζ) CAR, pCDCAR1 Human 6H6 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7105 Anti-CD40 (6H6) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 6H6 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7106 Anti-CD40 (ChiLob 7/4) h(CD28-CD3ζ) CAR, pCDCAR1 Human ChiLob 7/4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7107 Anti-CD40 (ChiLob 7/4) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human ChiLob 7/4 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7108 Anti-CD40 (2.174) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2.174 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7109 Anti-CD40 (2.174) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 2.174 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7117 Anti-CD40 (AB009) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human AB009 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7118 Anti-CD40 (C40M63) h(CD28-CD3ζ) CAR, pCDCAR1 Human C40M63 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7119 Anti-CD40 (C40M63) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human C40M63 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7120 Anti-CD40 (ACS30S) h(CD28-CD3ζ) CAR, pCDCAR1 Human ACS30S Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7121 Anti-CD40 (ACS30S) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human ACS30S Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7122 Anti-CD40 (1E10) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1E10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7123 Anti-CD40 (1E10) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 1E10 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7124 Anti-CD40 (269-B11) h(CD28-CD3ζ) CAR, pCDCAR1 Human 269-B11 Hamster scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7125 Anti-CD40 (269-B11) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 269-B11 Hamster scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7126 Anti-CD40 (FGK45) h(CD28-CD3ζ) CAR, pCDCAR1 Human FGK45 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP7127 Anti-CD40 (FGK45) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human FGK45 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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