MDA5

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

CAR Vector Products

Target Species:
Antibody Host:
Receptor Construction:
Vector Type:
Targeting Cell Type:

CAT	Product Name	Target Species	Antibody Clone	Antibody Host	Receptor Construction	Vector Type	Targeting Cell Type	CAR Vector Type	Inquiry & Datasheet
CAART-LX099	Anti-MDA5 h(CD28-CD3ζ) CAART, pCDCAAR1	Human		Mouse	scFv-CD28-CD3ζ	Lentiviral vector	B cell		Add to Cart Datasheet
CAART-LX100	Anti-MDA5 h(4-1BB-CD3ζ) CAART, pCDCAAR1	Human		Mouse	scFv-4-1BB-CD3ζ	Lentiviral vector	B cell		Add to Cart Datasheet

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MDA5

CAR Vector Products