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PAD4

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

PAD4 catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAART-LX181 Anti-PAD4 (102) h(CD28-CD3ζ) CAART, pCDCAAR1 Human 102 Human scFv-CD28-CD3ζ Lentiviral vector B cell   Add to Cart   Datasheet
CAART-LX182 Anti-PAD4 (17) h(CD28-CD3ζ) CAART, pCDCAAR1 Human 17 Human scFv-CD28-CD3ζ Lentiviral vector B cell   Add to Cart   Datasheet
CAART-LX183 Anti-PAD4 (102) h(4-1BB-CD3ζ) CAART, pCDCAAR1 Human 102 Human scFv-4-1BB-CD3ζ Lentiviral vector B cell   Add to Cart   Datasheet
CAART-LX184 Anti-PAD4 (17) h(4-1BB-CD3ζ) CAART, pCDCAAR1 Human 17 Human scFv-4-1BB-CD3ζ Lentiviral vector B cell   Add to Cart   Datasheet
XS-1022-ZP281 Anti-PAD4 (M18) h(41BB-CD3ζ) CAR, pCDCAR1 Human M18 Mouse scFv-41BB-CD49ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP282 Anti-PAD4 (M18) h(CD28-CD3ζ) CAR, pCDCAR1 Human M18 Mouse scFv-CD28-CD49ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP283 Anti-PAD4 (14B7) h(41BB-CD3ζ) CAR, pCDCAR1 Human 14B7 Mouse scFv-41BB-CD50ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP284 Anti-PAD4 (14B7) h(CD28-CD3ζ) CAR, pCDCAR1 Human 14B7 Mouse scFv-CD28-CD50ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP285 Anti-PAD4 (1H) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1H Mouse scFv-41BB-CD51ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP286 Anti-PAD4 (1H) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1H Mouse scFv-CD28-CD51ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP287 Anti-PAD4 (A11) h(CD28-CD3ζ) CAR, pCDCAR1 Human A11 Humanized scFv-41BB-CD50ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP289 Anti-PAD4 (G8) h(41BB-CD3ζ) CAR, pCDCAR1 Human G8 Humanized scFv-41BB-CD51ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP290 Anti-PAD4 (G8) h(CD28-CD3ζ) CAR, pCDCAR1 Human G8 Humanized scFv-CD28-CD51ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP291 Anti-PAD4 (G9) h(41BB-CD3ζ) CAR, pCDCAR1 Human G9 Humanized scFv-41BB-CD52ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP292 Anti-PAD4 (G9) h(CD28-CD3ζ) CAR, pCDCAR1 Human G9 Humanized scFv-CD28-CD52ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP459 Anti-PAD4 (10) h(41BB-CD3ζ) CAR, pCDCAR1 Human 10 Human scFv-41BB-CD80ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP460 Anti-PAD4 (10) h(CD28-CD3ζ) CAR, pCDCAR1 Human 10 Human scFv-CD28-CD80ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP461 Anti-PAD4 (16) h(41BB-CD3ζ) CAR, pCDCAR1 Human 16 Human scFv-41BB-CD79ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP462 Anti-PAD4 (16) h(CD28-CD3ζ) CAR, pCDCAR1 Human 16 Human scFv-CD28-CD79ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP463 Anti-PAD4 (17) h(CD28-CD3ζ) CAR, pCDCAR1 Human 17 Human scFv-41BB-CD80ζ Lentiviral vector T cell   Add to Cart   Datasheet
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