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Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states. Tumoral PD-L1 expression status has been shown to be prognostic in multiple tumor types, including melanoma (MEL), renal cell carcinoma (RCC), and non–small-cell lung cancer (NSCLC).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| XS-1122-YF101 | Anti-PD-L1 KIR CAR (scFv-KIR2DS2-DAP12, XW-101), pCDCAR1 | Human | XW-101 | Humanized | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF102 | Anti-PD-L1 KIR CAR (scFv-KIR2DS2-DAP12, XW-102), pCDCAR1 | Human | XW-102 | Humanized | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF103 | Anti-PD-L1 KIR CAR (scFv-KIR2DS2-DAP12, XW-103), pCDCAR1 | Human | XW-103 | Humanized | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF104 | Anti-PD-L1 KIR CAR (scFv-KIR2DS2-DAP12, XW-104), pCDCAR1 | Human | XW-104 | Humanized | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF105 | Anti-PD-L1 KIR CAR (scFv-KIR2DS2-DAP12, XW-105), pCDCAR1 | Human | XW-105 | Humanized | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF106 | Anti-PD-L1 KIR CAR (scFv-KIR2DS2-DAP12, XW-106), pCDCAR1 | Mouse | XW-106 | Rat | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF107 | Anti-PD-L1 KIR CAR (scFv-KIR2DS2-DAP12, XW-107), pCDCAR1 | Human | XW-107 | Humanized | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-0123-ZP106 | Anti-PD-L1 (Atezolizumab) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | Atezolizumab | Humanized | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0323-ZP98 | Anti-PD-L1 (Durvalumab scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | Durvalumab | Humanized | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0323-ZP99 | Anti-PD-L1 (huAB4 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | huAB4 | Humanized | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0323-ZP100 | Anti-PD-L1 (CTI-48 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | CTI-48 | Humanized | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0323-ZP101 | Anti-PD-L1 (hu333-4A2 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | hu333-4A2 | Humanized | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0323-LX267 | Anti-PD-L1 VHH(X3XH267) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH267 | VHH-CD28-41BB-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX268 | Anti-PD-L1 VHH(X3XH268) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH268 | VHH-CD28-41BB-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX269 | Anti-PD-L1 VHH(X3XH269) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH269 | VHH-CD28-41BB-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX270 | Anti-PD-L1 VHH(X3XH270) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH270 | VHH-CD28-41BB-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX271 | Anti-PD-L1 VHH(X3XH271) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH271 | VHH-CD28-41BB-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX272 | Anti-PD-L1 VHH(X3XH272) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH272 | VHH-CD28-41BB-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX273 | Anti-PD-L1 VHH(X3XH273) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH273 | VHH-CD28-41BB-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX274 | Anti-PD-L1 VHH(X3XH274) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH274 | VHH-CD28-41BB-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0823-LX83 | Anti-hPD-L1 (736) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | 736 | Adenoviral vectors |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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