PM-Scl

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

CAR Vector Products

Target Species:
Antibody Host:
Receptor Construction:
Vector Type:
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CAT	Product Name	Target Species	Antibody Clone	Antibody Host	Receptor Construction	Vector Type	Targeting Cell Type	CAR Vector Type	Inquiry & Datasheet
CAART-LX189	Anti-PM-Scl h(CD28-CD3ζ) CAART, pCDCAAR1	Human		Mouse	scFv-CD28-CD3ζ	Lentiviral vector	B cell		Add to Cart Datasheet
CAART-LX190	Anti-PM-Scl h(4-1BB-CD3ζ) CAART, pCDCAAR1	Human		Mouse	scFv-4-1BB-CD3ζ	Lentiviral vector	B cell		Add to Cart Datasheet

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PM-Scl

CAR Vector Products