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TIF-1γ

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

TIF-1γ acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAART-LX231 Anti-TIF-1γ h(CD28-CD3ζ) CAART, pCDCAAR1 Human XHM501 Mouse scFv-CD28-CD3ζ Lentiviral vector B cell   Add to Cart   Datasheet
CAART-LX232 Anti-TIF-1γ h(4-1BB-CD3ζ) CAART, pCDCAAR1 Human XHM501 Mouse scFv-4-1BB-CD3ζ Lentiviral vector B cell   Add to Cart   Datasheet
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