As a leading CRO of antibody generation and development, Creative Biolabs offers application-specific antibody development services to global clients. With experienced scientists and advanced technology, we have established a series of high-quality in vitro diagnostic (IVD) antibody development services against biomarkers of different diseases. Here, we introduce our IVD antibody development services for complement C5a marker.
Signaling Pathways of Complement C5a
The complement-activated product, complement C5a, is a glycoprotein with a 74 amino acid. Upon activation of the complement cascade, C5a acts as a potent pro-inflammatory mediator cleaved enzymatically from its precursor. The C5a receptors allow C5a to elicit a broad range of effects, which are widely present throughout the body. Thus, C5a has been regarded as a significant pathogenic driver in a number of immuno-inflammatory diseases and makes C5a inhibition an attractive therapeutic strategy. C5a/C5aR signaling pathway can cooperate with TLR-4 activation by LPS on macrophages. The complement system not only represents an effective innate immune mechanism of host defense to eradicating microbial pathogens, but it is also widely involved in many forms of acute and chronic inflammatory diseases including sepsis, acute lung injury, ischemia-reperfusion injury, and asthma, to give just a few examples.
Fig.1 C5a/C5aR signaling pathway. (Merle. 2015)
Complement C5a Marker of Sepsis
C5a often functions as a powerful inflammatory mediator and play an important role in the pathological development of many inflammatory diseases including the complement system such as sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, psoriasis. As a strong chemoattractant, C5a is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, inactivation of phagocytic cells and release of granule-based enzymes and generation of oxidants, all of which may contribute to innate immune functions or tissue damage. In summary, C5a has been known as a vital bridge between innate and adaptive immune functions, extending the roles of C5a in inflammation. Related research has shown that the cellular and molecular mechanisms of C5a in the development of inflammatory disorders, sepsis, acute lung injury, ischemia-reperfusion injury, and asthma.
Complement C5a Marker Antibodies
IVD Antibody Development Services Targeting Complement C5a Marker
IVD antibodies are extensively used in immunodiagnostic tools for disease screening and therapeutic monitoring. Through our role as a leading antibody service provider, Creative Biolabs is well-positioned to develop high-quality anti-complement C5a antibodies. Besides antibody generation, Creative Biolabs also offers diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.
Creative Biolabs has successfully completed numerous IVD antibody generation and development projects for clients across the globe. For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
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