Creative Biolabs is a world-leading service provider of application-specific antibody development. Here, we introduce our in vitro diagnostic (IVD) antibody development and immunoassay development services targeting the NF-κB marker. We are confident that our commitment to science and research will enable us to offer you the best products and services.
Introduction of NF-κB
Nuclear factor κB (NF-κB) is a ubiquitously expressed transcription factor that belongs to the NF-κB protein family which shares a highly conserved DNA-binding and dimerization domain termed Rel homology region (RHR) that enables them to homo- or heterodimerize. Studies have suggested that NF-κB is able to mediate signal-induced expression of numerous genes involved in different biological processes, including immune responses, inflammation, cell growth, and survival. Generally, NF-κB transcription factors can be activated as a response to a variety of signals, including cytokines, pathogens, injuries, and other stressful conditions. And inappropriate activation of the NF-κB signaling pathways has been linked to autoimmunity, chronic inflammation, and various cancers.
Fig.1 Activation of NF-κB can be described by distinct pathways, according to the mechanism of IκB degradation. (Godwin., 2013)
NF-κB Marker of Sepsis
Severe sepsis is a complex syndrome characterized by an amplified host inflammatory response leading to organ dysfunction. During severe infections, NF-κB is crucial for the regulation of immune/inflammatory responses and the control of cell proliferation/apoptosis. It has been reported that inhibition of NF-κB activation results in systemic hypotension, ameliorates septic myocardial dysfunction and vascular derangement, inhibits multiple proinflammatory gene expression, and prevents microvascular endothelial leakage. Most importantly, NF-κB activity was significantly higher in human subjects with sepsis. What's more, greater levels of NF-κB activity are associated with a higher rate of mortality and worse clinical outcome. In this case, the level of NF-κB can be used as a specific marker for the diagnosis of sepsis.
Fig.2 NF-κB activity in Drosophila melanogaster after septic injury with Staphylococcus aureus. (Kaynar., 2016)
IVD Antibody Development Services for NF-κB Marker
In recent years, IVD technologies are undergoing rapid development. IVD antibodies have extensively used as important tools for the diagnosis of numerous diseases, conditions, or infections. With state-of-the-art technology and professional scientists, Creative Biolabs is capable of providing a full range of IVD antibody development services for our worldwide customers. Besides, we also offer diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.
If you are interested in the services we provide, please don't hesitate to contact us and get a quote.
References
For Research Use Only.
