Working in the field of antibody development for many years, Creative Biolabs has gained a wealth of experience in providing high-quality application-specific antibody development services. Especially, Creative Biolabs has launched a series of in vitro diagnostic (IVD) antibody development services targeting a number of disease markers. Here, we introduce our IVD antibody development services against TREM-1 marker.
Introduction of TREM-1
Triggering receptor expressed on myeloid cells 1 (TREM-1) is a protein encoded by the human TREM1 gene. As a member of the Ig superfamily, it is a 30-kDa glycoprotein receptor containing an ectodomain of the Ig-like V-type, a transmembrane part, and a short intracytoplasmic domain. Generally, TREM-1 is expressed on neutrophils and monocytes and plays an important role in systemic infections. Engagement of TREM-1 on the surface of the cell membrane leads to activation of a cascade of intracellular events that result in inflammatory response including the production of cytokines, chemokines, and reactive oxygen species. Furthermore, TREM-1 signaling leads to degranulation of neutrophils and increased phagocytosis.
Fig.1 Schematic presentation of the role of TREM1 in inflammatory responses (Colonna., 2003)
TREM-1 Marker of Sepsis
Severe sepsis is a major cause of morbidity and mortality in humans for it can result in activation of various immunological mechanisms and coagulation cascades that are detrimental to the host. Studies have shown that the expression of membrane-bound TREM-1 by effector cells is dramatically increased in skin, biological fluids and tissues infected by Gram-positive and Gram-negative bacteria and fungi, especially in patients with sepsis. Furthermore, the soluble form of this receptor (sTREM-1) which can be measured in biological fluid also increases. In this case, the rapid assessment of sTREM-1 concentration could be used as a valuable tool for the diagnosis of infection, particularly with regard to its plasma levels in sepsis.
Fig.2 Overview of the role of TREM-1 in sepsis (Gibot., 2005)
IVD Antibody Development Services for TREM-1 Marker
IVD technologies are undergoing rapid development in recent years. IVD antibodies have been extensively used for the diagnosis of numerous diseases, including but not limited to sepsis. With years of experience and advanced technology, Creative Biolabs is able to provide a full range of high-quality and cost-effective biomarker-specific antibody development services. Especially, we help develop novel anti-TREM-1 antibodies for your IVD projects. Having completed a number of IVD antibody generation and development projects, Creative Biolabs is confident to offer you the best products and services to promote your project a success.
If you are interested in the service we can provide, please feel free to contact us and get a quote. We will get in touch with you as soon as possible.
References
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