Other Services
Beyond our core gene therapy offerings, Creative Biolabs provides specialized analytical and screening services that support comprehensive drug discovery and development programs. Our Other Services portfolio encompasses advanced transcriptome analysis and cellular functional assessments, offering researchers powerful tools to understand molecular mechanisms, validate therapeutic targets, and ensure drug safety. These complementary services integrate seamlessly with our primary offerings, providing holistic solutions that accelerate research progress and enhance therapeutic development outcomes.
Our Services
Ensure the safety profile of your therapeutic candidates with our comprehensive mitochondrial toxicity assessment services, addressing a critical aspect of drug development and safety evaluation. Mitochondrial dysfunction is implicated in numerous diseases and can be a significant side effect of therapeutic interventions, making thorough toxicity screening essential. Our multi-parametric approach evaluates key indicators of mitochondrial health including oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) using state-of-the-art Seahorse technology, membrane potential assessment via JC-1 fluorescence, reactive oxygen species (ROS) and superoxide detection, calcium dynamics monitoring, and mitochondrial permeability transition pore (MPTP) analysis. We also provide high-quality mitochondrial extraction services for detailed biochemical studies. This comprehensive panel enables early detection of mitochondrial toxicity, helping researchers identify potential safety issues before advancing to costly late-stage development. Our services support drug screening, mechanism of toxicity studies, and safety profiling across various therapeutic modalities.
Unlock the full potential of transcriptome analysis with our comprehensive RNA profiling services, designed to provide deep insights into gene expression patterns and regulatory mechanisms. Our cutting-edge RNA sequencing platform enables precise quantification and characterization of all RNA species, from coding mRNAs to regulatory non-coding RNAs. We offer three specialized profiling approaches: Total RNA profiling for comprehensive transcriptome analysis including both coding and non-coding RNAs; Small RNA analysis for microRNA discovery and expression profiling; and mRNA profiling for accurate transcript abundance estimation and alternative splicing analysis. Our services accommodate diverse sample types including liquid biopsies, fresh frozen and FFPE tissues, exosomes, serum, and plasma. With advanced bioinformatics capabilities, we deliver not just raw data but meaningful insights through differential expression analysis, pathway enrichment, and integration with other epigenomic datasets. This powerful analytical tool supports drug target identification, biomarker discovery, and mechanism of action studies across all stages of therapeutic development.
Service Integration and Applications
- Cross-Platform Synergies: Our RNA profiling and mitochondrial toxicity services complement our core gene therapy offerings, enabling comprehensive evaluation of therapeutic effects at both molecular and cellular levels.
- Drug Discovery Support: These analytical services accelerate target validation, lead optimization, and safety assessment phases of drug development, providing critical data for informed decision-making.
- Biomarker Development: RNA profiling identifies expression signatures associated with disease states or treatment responses, while mitochondrial assessments reveal metabolic biomarkers of cellular stress and toxicity.
- Mechanism of Action Studies: Combined transcriptomic and functional analyses elucidate how therapeutic interventions affect cellular pathways, energy metabolism, and stress responses.
- Quality by Design: Integration of these services early in development helps identify potential issues, optimize therapeutic design, and establish safety profiles that support regulatory submissions.
