Nucleic Acid Services

Creative Biolabs stands at the forefront of nucleic acid-based therapeutic development, offering comprehensive services that span the entire spectrum of RNA and DNA technologies. Our integrated platform combines cutting-edge synthesis capabilities with advanced screening and validation services, providing researchers and pharmaceutical companies with complete solutions for nucleic acid drug discovery and development. From novel circular RNAs to established antisense oligonucleotides and siRNA therapeutics, our expertise covers all major categories of nucleic acid therapeutics, supported by state-of-the-art facilities and decades of accumulated technical knowledge.

Our Services

siRNA In Vitro Screening Service

Accelerate your drug discovery efforts with our sophisticated siRNA screening platform, designed to identify and validate therapeutic targets with unprecedented efficiency. Our siRNA screening services offer both arrayed and pooled formats, each optimized for specific research objectives and cell types. Arrayed screening enables high-content analysis with single-gene resolution, ideal for studying complex phenotypes and cellular responses to various stimuli. Pooled screening excels in genome-wide studies and selection-based assays, particularly for identifying drug resistance genes and essential cellular factors. Our comprehensive RNAi libraries include chemically synthesized siRNAs, vector-encoded shRNAs, and esiRNAs, with specialized lentiviral options for hard-to-transfect primary cells. Advanced detection methods, from multiparametric imaging to next-generation sequencing, ensure robust data generation and target identification that traditional screening approaches might miss.

Circular RNAs (circRNAs) Service

Unlock the potential of circular RNAs with our comprehensive circRNA platform, leveraging these uniquely stable molecules for next-generation therapeutics and research applications. Our services encompass custom circular RNA synthesis, analysis, and delivery solutions, taking advantage of circRNAs' exceptional stability and resistance to nuclease degradation. With half-lives 2.5 times longer than linear RNA, circRNAs offer unprecedented advantages for sustained therapeutic expression. Our team specializes in designing and producing circRNAs with specific functional properties, including those capable of protein expression through IRES incorporation. Combined with our advanced lipid nanoparticle formulation services, we enable efficient delivery of circRNAs in various model systems, making these innovative molecules accessible for vaccine development, protein replacement therapy, and novel therapeutic applications.

Antisense Oligonucleotide (ASO) Development Service

Experience the power of integrated ASO development through our comprehensive platform that streamlines the journey from target identification to therapeutic validation. Our one-stop ASO services eliminate the complexities of multi-vendor coordination by providing complete solutions under one roof. Beginning with sophisticated sequence design algorithms and extending through gram-scale synthesis, formulation development, and in vitro/in vivo validation, we handle every aspect of ASO development. Our expertise spans all three generations of ASO chemistry, including phosphorothioate modifications, 2'-MOE gapmers, and advanced LNA/PNA structures. With specialized capabilities in ASO-antibody conjugation for enhanced targeting and comprehensive off-target analysis protocols, we ensure that your ASO candidates meet the highest standards for efficacy and safety. Our animal model expertise, including mdx mice for DMD and SOD1-G93A for ALS, provides relevant disease contexts for therapeutic evaluation.

Why Choose Us

• Integrated Platform Approach: Our unified platform eliminates the need for multiple vendors, providing seamless transitions between synthesis, modification, screening, and validation stages while maintaining consistent quality standards throughout your project.
• Technical Excellence: Leveraging state-of-the-art synthesis technologies, advanced analytical capabilities, and proven screening methodologies, we deliver nucleic acid therapeutics with exceptional purity, specificity, and biological activity.
• Comprehensive Expertise: Our team combines deep knowledge across all nucleic acid modalities—from emerging circRNA technologies to established ASO and siRNA platforms—ensuring optimal selection and design for your therapeutic goals.
• Customized Solutions: Every project benefits from tailored approaches, whether it's specialized chemical modifications, unique delivery formulations, or custom screening protocols designed to address your specific research questions.
• End-to-End Support: From initial consultation through final validation, our dedicated project managers and technical specialists provide continuous support, regular updates, and strategic guidance to keep your projects on track.
• Proven Track Record: Years of experience in nucleic acid therapeutics development, combined with successful delivery of hundreds of custom projects, demonstrate our capability to handle even the most challenging requirements.