Other Custom Formulation & Conjugation Services
At Creative Biolabs, we continuously expand our expertise to offer cutting-edge gene therapy solutions beyond traditional approaches. Our comprehensive portfolio includes specialized delivery systems and screening services designed to meet diverse research and therapeutic needs.
Specialized Delivery Systems
Develop highly specific aptamer-guided RNA delivery systems through our specialized screening services. These nucleic acid aptamers serve as molecular targeting moieties with exceptional selectivity, lack of immunogenicity, and facile conjugation chemistry for precise siRNA delivery to target cells.
Benefit from our versatile nanoparticle platforms designed for enhanced RNAi delivery. Our modular approach allows customization of organic (liposomes, micelles) and inorganic (MSNs, gold nanoparticles) carriers with specific targeting ligands, providing optimal protection, stability, and cellular uptake for your therapeutic applications.
Benefit from our versatile nanoparticle platforms designed for enhanced RNAi delivery. Our modular approach allows customization of organic (liposomes, micelles) and inorganic (MSNs, gold nanoparticles) carriers with specific targeting ligands, providing optimal protection, stability, and cellular uptake for your therapeutic applications.
Custom Nucleic Acid Nanostructure Service
Benefit from our versatile nanoparticle platforms designed for enhanced RNAi delivery. Our modular approach allows customization of organic (liposomes, micelles) and inorganic (MSNs, gold nanoparticles) carriers with specific targeting ligands, providing optimal protection, stability, and cellular uptake for your therapeutic applications.
Leverage nature's own delivery system with our exosome-based solutions. These nano-sized vesicles (40-120nm) naturally shuttle RNA between cells, offering high stability in circulation, efficient cellular entry, and minimal immunogenicity. Our service includes various exosome origins and targeted delivery options for effective siRNA transfer.
Cell and Biological Vector Systems
Development of Polyplexes as Gene Delivery System
Explore our advanced polyplex formulations for non-viral gene therapy. Our decationized polyplexes feature neutral polymer compositions with PEG corona and cross-linked cores, providing excellent stability, minimal toxicity, and improved biodistribution for systemic gene delivery applications.
Development of Dendrimers as Gene Delivery System
Utilize our precisely engineered dendrimer platforms for efficient nucleic acid delivery. These highly branched polymeric structures offer controllable size, multifunctional surfaces, and customizable properties. We provide various generations of PAMAM and DGL dendrimers with biocompatible modifications for enhanced transfection efficiency.
Development of Stem Cells as Gene Delivery System
Harness the regenerative potential of stem cells as living delivery vehicles for therapeutic genes. Our comprehensive platform includes MSCs and NSCs with homing capabilities, enabling targeted delivery to injured tissues while providing both cellular replacement and therapeutic gene expression.
Development of Dendritic Cell as Gene Delivery System
Combine immunotherapy with gene therapy using our dendritic cell platforms. These powerful antigen-presenting cells can be genetically modified to express specific antigens or modulate immune responses, offering promising approaches for cancer vaccines and immunomodulation.
Development of Bacteria as Gene Delivery System
Explore innovative bactofection strategies for targeted gene delivery. Our attenuated bacterial strains, including E. coli, Salmonella, and Bifidobacterium, can penetrate tissues and release therapeutic plasmids directly at target sites, particularly useful for solid tumor treatment and alternative gene therapy approaches.
