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pCDCAR1 Bpep h(γ), T (CAR-T-1-M402-G)

The vector of anti-Bpep chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human Bpep. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-Bpep antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of ovarian tumor.

Details

  • Target
  • Bpep
  • Target Species
  • Human
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Ovarian tumor
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcεRIγ
  • Discription of Signaling Cassetes
  • FcεRIγ
    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
  • Antibody Clone
  • CC49
  • Antibody Host
  • Humanized

Target

  • Gene Name
  • transcription factor BPE
  • Official Symbol
  • Bpep
  • Synonyms
  • Bpep; transcription factor BPE; ovarian tumor; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; CC49

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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