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NKG2D

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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-ZP096 Anti-NKG2D (ED) m(41BB-CD3ζ) CAR, pCDCAR1 Mouse ED Humanized scFv-4-1BB-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP097 Anti-NKG2D (ED) m(CD28-CD3ζ) CAR, pCDCAR1 Mouse ED Humanized scFv-CD28-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP104 Anti-NKG2D (KYK-1.0) h(41BB-CD3ζ) CAR, pCDCAR1 Human KYK-1.0 Mouse scFv-4-1BB-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP105 Anti-NKG2D (KYK-1.0) h(CD28-CD3ζ) CAR, pCDCAR1 Human KYK-1.0 Mouse scFv-CD28-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP184 Anti-NKG2D (ADI-27705) h(CD28-CD3ζ) CAR, pCDCAR1 Human ADI-27705 Mouse scFv-CD28-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP185 Anti-NKG2D (ADI-27705) h(41BB-CD3ζ) CAR, pCDCAR1 Human ADI-27705 Mouse scFv-4-1BB-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP8204 Anti- NKG2D (KYK-2.0) h(CD28-CD3ζ) CAR, pCDCAR1 Human KYK-2.0 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8213 Anti- NKG2D (MS) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human MS Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8214 Anti- NKG2D (16F16) h(CD28-CD3ζ) CAR, pCDCAR1 Human 16F16 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8215 Anti- NKG2D (16F16) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 16F16 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8216 Anti- NKG2D (21F2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 21F2 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8217 Anti- NKG2D (21F2) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 21F2 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8218 Anti- NKG2D (MAB0840) h(CD28-CD3ζ) CAR, pCDCAR1 Human MAB0840 Hamster scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8219 Anti- NKG2D (MAB0840) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human MAB0840 Hamster scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8220 Anti- NKG2D (BAT221) h(CD28-CD3ζ) CAR, pCDCAR1 Human BAT221 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-SB-LX0376 Anti-NKG2D (KYK-1.0) h(CD28-CD3ζ) CAR, pSBCAR1 Human KYK-1.0 Human scFv-CD28-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
CAR-SB-LX0377 Anti-NKG2D (KYK-2.0) h(CD28-CD3ζ) CAR, pSBCAR1 Human KYK-2.0 Human scFv-CD28-CD3ζ Sleeping Beauty (SB) transposon T cell   Add to Cart   Datasheet
XS-0622-ZP3180 Anti-NKG2D h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 Human VHH1-VHH2-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
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