Close

PD-1

Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a cell surface receptor that plays an important role in down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 is an immune checkpoint and guards against autoimmunity through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-L1, the ligand for PD1, is highly expressed in several cancers and hence the role of PD1 in cancer immune evasion is well established. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. Many tumor cells express PD-L1, an immunosuppressive PD-1 ligand; inhibition of the interaction between PD-1 and PD-L1 can enhance T-cell responses in vitro and mediate preclinical antitumor activity. This is known as immune checkpoint blockade. A number of cancer immunotherapy agents that target the PD-1 receptor have been developed. One such anti-PD-1 antibody drug, nivolumab, (Opdivo - Bristol Myers Squibb), produced complete or partial responses in non-small-cell lung cancer, melanoma, and renal-cell cancer, in a clinical trial with a total of 296 patients

Associated Disease
  • B-cell malignancies
  • Acute lymphoblastic leukemia (ALL)
  • CAR Vector Products
  • CAR Viral Particles
Loading...
  • Antibody Clone:
  • Antibody Host:
  • Receptor Construction:
  • Vector Type:
CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-1-L345-2 Anti-PD-1 scFv h(CD28) CART, pCDCAR1 Human J43 Mouse scFv-CD28 Lentiviral T cell   Inquiry
  Datasheet
CAR-T-1-L345-G Anti-PD-1 scFv h(FcεRIγ) CART, pCDCAR1 Human J43 Mouse scFv-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-1-L345-Z Anti-PD-1 scFv h(CD3ζ) CART, pCDCAR1 Human J43 Mouse scFv-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L345-2G Anti-PD-1 scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human J43 Mouse scFv-CD28-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L345-2Z Anti-PD-1 scFv h(CD28-CD3ζ) CART, pCDCAR1 Human J43 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L345-4G Anti-PD-1 scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human J43 Mouse scFv-CD4-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L345-4Z Anti-PD-1 scFv h(CD4-CD3ζ) CART, pCDCAR1 Human J43 Mouse scFv-CD4-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L345-8Z Anti-PD-1 scFv h(CD8-CD3ζ) CART, pCDCAR1 Human J43 Mouse scFv-CD8-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L345-BZ Anti-PD-1 scFv h(41BB-CD3ζ) CART, pCDCAR1 Human J43 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L345-CZ Anti-PD-1 scFv h(b2c-CD3ζ) CART, pCDCAR1 Human J43 Mouse scFv-b2c-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-3-L345-2BZ Anti-PD-1 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human J43 Mouse scFv-CD28-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-3-L345-2XZ Anti-PD-1 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human J43 Mouse scFv-CD28-OX40-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-ZP246 Anti-PD-1 (Pembrolizumab) h(CD28-CD3ζ) CAR, pCDCAR1 Human Pembrolizumab Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP247 Anti-PD-1 (Pembrolizumab) h(41BB-CD3ζ) CAR, pCDCAR1 Human Pembrolizumab Humanized scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP248 Anti-PD-1 (5C4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5C4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP249 Anti-PD-1 (5C4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5C4 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP250 Anti-PD-1 (Pidilizumab) h(CD28-CD3ζ) CAR, pCDCAR1 Human Pidilizumab Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP251 Anti-PD-1 (Pidilizumab) h(41BB-CD3ζ) CAR, pCDCAR1 Human Pidilizumab Humanized scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP252 Anti-PD-1 (1E3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1E3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP253 Anti-PD-1 (1E3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1E3 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP254 Anti-PD-1 (1E8) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1E8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP255 Anti-PD-1 (1E8) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1E8 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP256 Anti-PD-1 (1H3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1H3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP257 Anti-PD-1 (1H3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1H3 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet

Key Updates

Receive the latest news and insights to your inbox.