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Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a cell surface receptor that plays an important role in down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 is an immune checkpoint and guards against autoimmunity through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-L1, the ligand for PD1, is highly expressed in several cancers and hence the role of PD1 in cancer immune evasion is well established. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. Many tumor cells express PD-L1, an immunosuppressive PD-1 ligand; inhibition of the interaction between PD-1 and PD-L1 can enhance T-cell responses in vitro and mediate preclinical antitumor activity. This is known as immune checkpoint blockade. A number of cancer immunotherapy agents that target the PD-1 receptor have been developed.
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| XS-1022-ZP329 | Anti-PD-1 (Mil85-6) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Mil85-6 | Human | scFv-41BB-CD57ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP330 | Anti-PD-1 (Mil85-6) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Mil85-6 | Human | scFv-CD28-CD57ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP331 | Anti-PD-1 (BAP049) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | BAP049 | Mouse | scFv-41BB-CD58ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP332 | Anti-PD-1 (BAP049) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | BAP049 | Mouse | scFv-CD28-CD58ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP333 | Anti-PD-1 (15H6) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 15H6 | Mouse | scFv-41BB-CD59ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP392 | Anti-PD-1 (H409A16) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | H409A16 | Humanized | scFv-CD28-CD68ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP393 | Anti-PD-1 (CBL078) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBL078 | Humanized | scFv-41BB-CD69ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP394 | Anti-PD-1 (CBL078) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBL078 | Humanized | scFv-CD28-CD69ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP395 | Anti-PD-1 (1D2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 1D2 | Mouse | scFv-41BB-CD68ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP396 | Anti-PD-1 (1D2) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 1D2 | Mouse | scFv-CD28-CD68ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP397 | Anti-PD-1 (M/YC-31) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | M/YC-31 | Mouse | scFv-41BB-CD69ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP398 | Anti-PD-1 (M/YC-31) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | M/YC-31 | Mouse | scFv-CD28-CD69ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP399 | Anti-PD-1 (hPD1.29H5L4) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | hPD1.29H5L4 | Humanized | scFv-41BB-CD70ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP401 | Anti-PD-1 (PD1-BM Ab) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | PD1-BM Ab | Humanized | scFv-41BB-CD69ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP402 | Anti-PD-1 (PD1-BM Ab) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | PD1-BM Ab | Humanized | scFv-CD28-CD69ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP403 | Anti-PD-1 (SSI-361) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | SSI-361 | Humanized | scFv-41BB-CD70ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP404 | Anti-PD-1 (SSI-361) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | SSI-361 | Humanized | scFv-CD28-CD70ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP405 | Anti-PD-1 (c109A) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | c109A | Chimeric | scFv-41BB-CD71ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP406 | Anti-PD-1 (c109A) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | c109A | Chimeric | scFv-CD28-CD71ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP407 | Anti-PD-1 (20B3.1) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 20B3.1 | Mouse | scFv-41BB-CD70ζ | Lentiviral vector | T cell | ||
| XS-0823-LX82 | Anti-hPD-1 (AB) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | AB | Adenoviral vectors |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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