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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a cell surface receptor that plays an important role in down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 is an immune checkpoint and guards against autoimmunity through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-L1, the ligand for PD1, is highly expressed in several cancers and hence the role of PD1 in cancer immune evasion is well established. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. Many tumor cells express PD-L1, an immunosuppressive PD-1 ligand; inhibition of the interaction between PD-1 and PD-L1 can enhance T-cell responses in vitro and mediate preclinical antitumor activity. This is known as immune checkpoint blockade. A number of cancer immunotherapy agents that target the PD-1 receptor have been developed.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-ZP246 | Anti-PD-1 (XR145) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | XR145 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP247 | Anti-PD-1 (XR145) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | XR145 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP248 | Anti-PD-1 (5C4) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 5C4 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP249 | Anti-PD-1 (5C4) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 5C4 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP250 | Anti-PD-1 (XR146) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | XR146 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP251 | Anti-PD-1 (XR146) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | XR146 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP252 | Anti-PD-1 (1E3) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 1E3 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP253 | Anti-PD-1 (1E3) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 1E3 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP254 | Anti-PD-1 (1E8) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 1E8 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP255 | Anti-PD-1 (1E8) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 1E8 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP295 | Anti-PD-1 (PD1-0103) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | PD1-0103 | Mouse | scFv-41BB-CD52ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP324 | Anti-PD-1 (10F8) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 10F8 | Mouse | scFv-CD28-CD56ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP325 | Anti-PD-1 (949) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 949 | Human | scFv-41BB-CD57ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP326 | Anti-PD-1 (949) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 949 | Human | scFv-CD28-CD57ζ | Lentiviral vector | T cell | ||
| XS-0323-LX1061 | Anti-PD-1 VHH(X3XH323) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH323 | VHH-CD28-OX40-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX1062 | Anti-PD-1 VHH(X3XH324) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH324 | VHH-CD28-OX40-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX1063 | Anti-PD-1 VHH(X3XH325) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH325 | VHH-CD28-OX40-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0323-LX1064 | Anti-PD-1 VHH(X3XH326) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector | Human | X3XH326 | VHH-CD28-OX40-CD3ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0723-LX15 | Anti-mPD-1 (ab2) m(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Mouse | ab2 | scFv-CD28-41BB-CD4ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0723-LX47 | Anti-cPD-1 (mab) c(CD28-41BB-CD3ζ) CAR, pCDCAR1 Vector | Canine | mab | scFv-CD28-41BB-CD4ζ | Lentiviral vector | T cell | CAR-T | ||
| XS-0823-LX82 | Anti-hPD-1 (AB) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | AB | Adenoviral vectors |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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