PD-1

Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a cell surface receptor that plays an important role in down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 is an immune checkpoint and guards against autoimmunity through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-L1, the ligand for PD1, is highly expressed in several cancers and hence the role of PD1 in cancer immune evasion is well established. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. Many tumor cells express PD-L1, an immunosuppressive PD-1 ligand; inhibition of the interaction between PD-1 and PD-L1 can enhance T-cell responses in vitro and mediate preclinical antitumor activity. This is known as immune checkpoint blockade. A number of cancer immunotherapy agents that target the PD-1 receptor have been developed. One such anti-PD-1 antibody drug, nivolumab, (Opdivo - Bristol Myers Squibb), produced complete or partial responses in non-small-cell lung cancer, melanoma, and renal-cell cancer, in a clinical trial with a total of 296 patients

Associated Disease
  • B-cell malignancies
  • Acute lymphoblastic leukemia (ALL)

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-L345-2 T cell First J43 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L345-G T cell First J43 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L345-Z T cell First J43 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L345-2G T cell Second J43 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L345-2Z T cell Second J43 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L345-4G T cell Second J43 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L345-4Z T cell Second J43 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L345-8Z T cell Second J43 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L345-BZ T cell Second J43 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L345-CZ T cell Second J43 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L345-2BZ T cell Third J43 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L345-2XZ T cell Third J43 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC401 J43 Lentivirus First scFv (J43)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC402 J43 Lentivirus First scFv (J43)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC403 J43 Lentivirus First scFv (J43)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC404 J43 Lentivirus Second scFv (J43)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC405 J43 Lentivirus Second scFv (J43)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC406 J43 Lentivirus Second scFv (J43)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC407 J43 Lentivirus Second scFv (J43)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC408 J43 Lentivirus Second scFv (J43)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC409 J43 Lentivirus Second scFv (J43)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC410 J43 Lentivirus Second scFv (J43)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC411 J43 Lentivirus Third scFv (J43)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC412 J43 Lentivirus Third scFv (J43)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

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Australia
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