Anti-Bmi1 DNA-encoded mAb (DMAb), pVAX1 (DMAb-0452-YY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-Bmi1 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
Bmi1

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
648

UniProt ID
P35226

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0452-YY	CBYY-1829	Mouse	Human	IgG1	Purified recombinant human Bmi1 protein fragments expressed in E.coli
DMAb-0496-YY	CBYY-1963	Mouse	Cat	IgG1	recombinant Bmi1 protein corresponding to residues 1-202 of mouse Bmi-1 acterial fusion protein of membrane proximal non repeat domain of human episialin
DMAb-0499-YY	CBYY-1970	Mouse	Rat	IgG1
DMAb-0500-YY	CBYY-1972	Mouse	Human	IgG1, κ	This BMI1 monoclonal antibody is generated from mouse immunized with BMI1 recombinant protein
DMAb-0154-YY	CBYY-0644	Mouse	Human	IgG1
DMAb-0155-YY	CBYY-0645	Mouse	Human	IgG1	Purified recombinant fragment of human BMI1 expressed in E. coli
DMAb-0156-YY	CBYY-0646	Hamster	Mouse	IgM
DMAb-0157-YY	CBYY-0647	Mouse	Human	IgG2b, κ	Human, Mouse
DMAb-0158-YY	CBYY-0648	Mouse	Human	IgG2a	Recombinant protein
DMAb-0159-YY	CBYY-0651	Hamster	Mouse	IgG1
DMAb-0160-YY	CBYY-0652	Mouse	Human	IgG2b, κ	Human Bmi1 protein [Swiss-Prot# P35226]
DMAb-0410-YY	CBYY-1686	Rabbit	Human	IgG1	Purified recombinant fragment of human BMI1 expressed in E. Coli
DMAb-1745-FY	CBFYM-0883	Mouse	Mouse	IgG2b	KLH conjugated synthetic peptide between 136-163 amino acids from mouse Bmi1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-Bmi1 DNA-encoded mAb (DMAb), pVAX1 (DMAb-0452-YY)

Specifications

Target

Customer Reviews and Q&As

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