Anti-EPCAM DNA-encoded mAb (DMAb), pVAX1 (DMAb-0200-CN)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-EPCAM DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
EPCAM

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
17075

UniProt ID
Q99JW5

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-1080-YY	4A7	Mouse		IgG1
DMAb-0250-FY	323/A3	Mouse	Human	IgG1, κ	MCF-7 human breast cancer cells
DMAb-0251-FY	60N5D8	Mouse	Human	IgG2b, κ	Within the range of amino acids 289-335 were used as the immunogen for the EpCAM antibody
DMAb-0252-FY	7B5C10	Mouse	Human	IgG1	Purified recombinant fragment of human EPCAM expressed in E.coli
DMAb-0253-FY	ABM4D85	Mouse	Human	IgG2a, κ
DMAb-0254-FY	AUA1	Mouse	Human	IgG1	LoVo cell line preparation
DMAb-0255-FY	B1368M	Mouse		IgG2b	Recombinant fusion of EpCAM peptide and human thioredoxin
DMAb-0256-FY	Ber-EP4	Mouse	Human	IgG1	BALB/C mice were immunized with human breast carcinoma cell line, MCF-7
DMAb-0257-FY	EGP40/1110	Mouse		IgG2b, κ	A recombinant human EpCAM fragment from the cytoplasmic domain
DMAb-0258-FY	EGP40/1372	Mouse	Human	IgG	A recombinant human EpCAM fragment from the extracellular domain
DMAb-0259-FY	EGP40/1373	Mouse	Human	IgG2b	Recombinant human EpCAM protein fragment from the extracellular domain
DMAb-0260-FY	EGP40/1555R	Rabbit	Human	IgG, κ	A synthetic peptide from the N-terminus of human TACSTD1 protein
DMAb-0261-FY	EGP40/1798	Mouse	Human	IgG2b, κ	Recombinant human EpCAM protein fragment from the extracellular domain
DMAb-0262-FY	EGP40/837	Mouse	Human	IgG1, κ	Recombinant human TACSTD1 protein
DMAb-0263-FY	Epcam/1158	Mouse		IgG1	It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas
DMAb-0264-FY	ESA214	Mouse	Human	IgG1	Small cell lung carcinoma. Remarks: Molecular weight of antigen: 40 kDa
DMAb-0265-FY	G8.8	Rat	Mouse	IgG2a	Glycoconjugates from Balb/C mouse derived medullary thymic epithelial cells
DMAb-0266-FY	HEA125	Mouse	Human	IgG1	Living human colon carcinoma cell line HT-29
DMAb-0267-FY	MOC-31	Mouse	Human	IgG1
DMAb-0268-FY	PAN-EpCAM Cocktail	Mouse	Human	IgG1, κ	Recombinant human Ep-CAM protein
DMAb-0269-FY	VU-1D9	Mouse	Human	IgG1
DMAb-0775-CQ	GZ-20	Mouse	Rat	IgG1
DMAb-0776-CQ	MOC-181	Mouse	Human	IgG2a
DMAb-0777-CQ	HEA-125	Mouse	Human	IgG1
DMAb-0778-CQ	B8-4	Mouse	Human	IgG1, κ	Recombinant human CD326 (EpCAM), Fc fusion protein
DMAb-0265-FY	G8.8	Rat	Mouse	IgG2a, κ
DMAb-0266-FY	HEA125	Mouse		IgG1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-EPCAM DNA-encoded mAb (DMAb), pVAX1 (DMAb-0200-CN)

Specifications

Target

Customer Reviews and Q&As

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