Epithelial cell adhesion molecule (EpCAM), also called DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation and differentiation. This protein can be used as a potential prognostic marker and as a potential target for immunotherapeutic strategies. EpCAM is associated with a lot of cancers including colon cancer, breast cancer, ovarian cancer, renal cancer (RCC), head and neck squamous cell carcinoma (HNSCC) and esophagus squamous cell carcinomas.
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