Anti-FAP DNA-encoded mAb (DMAb), pVAX1 (DMAb-0833-CQ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-FAP DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
FAP

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
2191

UniProt ID
Q12884

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0833-CQ	CBXF-2568	Mouse		IgG1	Sf 21-derived recombinant human Fibroblast Activation Protein alpha/FAP, Leu26-Asp760, Accession # Q12884
DMAb-0834-CQ	CBXF-2140	Mouse		IgG1	Recombinant Human alpha FAP
DMAb-0835-CQ	CBXF-0297	Mouse		IgG2a
DMAb-0836-CQ	F11-24	Mouse		IgG1
DMAb-0837-CQ	CBXF-0295	Mouse		IgG1
DMAb-0838-CQ	CBXF-0296	Mouse		IgG2a, κ
DMAb-0839-CQ	CBXF-1919	Mouse		IgG1
DMAb-0840-CQ	CBXF-2845	Mouse		IgG2a, κ	FAP (AAH26250, 525aa-624aa) partial recombinant protein with GST tag
DMAb-0841-CQ	CBXF-2846	Mouse		IgG	FAP (AAH26250, 525aa-624aa) partial recombinant protein with GST tag
DMAb-0842-CQ	CBXF-2847	Mouse		IgG	Recombinant corresponding to aa26-760 of human Fibroblast Activation Protein alpha expressed in Sf 21 (Q12884)
DMAb-0843-CQ	CBXF-2848	Mouse		IgG1	Human Fibroblast Activation Protein
DMAb-0844-CQ	CBXF-1657	Mouse		IgG1	Recombinant protein corresponding to human alpha FAP
DMAb-0845-CQ	CBXF-1435	Mouse		IgG2a, κ	Recombinant protein corresponding to a portion of amino acids within aa525-625 of human FAP with a GST tag. MW of tthe GST tag alone is 26kD. (Q12884)

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-FAP DNA-encoded mAb (DMAb), pVAX1 (DMAb-0833-CQ)

Specifications

Target

Customer Reviews and Q&As

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