Anti-HNF4A DNA-encoded mAb (DMAb), pVAX1 (DMAb-1217-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-HNF4A DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
HNF4A

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
3172

UniProt ID
P41235

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-1217-FY	CBFYH-3177	Rabbit	Human	IgG
DMAb-1218-FY	H1415	Mouse	Human	IgG2a	Recombinant human HNF-4 alpha/NR2A1, aa 393-461
DMAb-1219-FY	CBFYH-2895	Mouse	Human	IgG1
DMAb-1220-FY	CBFYH-1596	Mouse	Human	IgG2a	Baculovirus-expressed recombinant human HNF4 alpha
DMAb-1221-FY	CBFYH-1597	Mouse	Human	IgG	Recombinant fragment of Human HNF4A
DMAb-1222-FY	CBFYH-1598	Mouse	Human	IgG2b	E. coli-derived recombinant human HNF-4 alpha/NR2A1, Val130-Ser330
DMAb-1223-FY	CBFYH-1599	Mouse	Human	IgG2a, κ	Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
DMAb-1224-FY	CBFYH-1600	Mouse	Human	IgG2a, κ
DMAb-1225-FY	CBFYH-1601	Rabbit	Human	IgG	Synthetic peptide corresponding to the sequence of human HNF4a
DMAb-1226-FY	CBFYH-1602	Mouse	Human	IgG2a, κ	Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MIEQIQFIKL FGMAKIDNLL QEMLLGGSPS DAPHAHHPLH PHLMQEHMGT NVIVANTMPT HLSNGQMSTP ETPQPSPPGG SGSEPYKLLP GAVATIVKPL SAIPQPTITK QEVI*
DMAb-1227-FY	CBFYH-1603	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 1-315 of human HNF4A produced in E. coli.
DMAb-1228-FY	CBFYH-1604	Mouse	Human	IgG2a	Human recombinant protein fragment corresponding to amino acids 1-315 of human HNF4A produced in E. coli.
DMAb-1229-FY	CBFYH-1605	Rabbit	Human	IgG
DMAb-1230-FY	CBFYH-1606	Rabbit	Human	IgG
DMAb-1231-FY	CBFYH-1607	Rabbit	Human	IgG
DMAb-1232-FY	CBFYH-1608	Rabbit	Human	IgG
DMAb-1233-FY	CBFYH-1609	Mouse	Human
DMAb-1234-FY	CBFYH-1610	Mouse	Human	IgG2a

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-HNF4A DNA-encoded mAb (DMAb), pVAX1 (DMAb-1217-FY)

Specifications

Target

Customer Reviews and Q&As

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