Anti-KDR DNA-encoded mAb (DMAb), pVAX1 (DMAb-1274-YY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-KDR DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
KDR

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
3791

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0038-YY	CBYY-0218	Mouse	Human		Synthetic peptide near the N-terminus of Mouse FLK-1 protein
DMAb-0039-YY	CBYY-0219	Mouse	Human		GST-fusion protein containing the carboxy-terminal 150aa residues of human VEGF receptor 2
DMAb-0040-YY	CBYY-0220	Mouse	Human		Recognizes human VEGF receptor 2 only when phosphorylated at Tyr951 at ~230kD. May crossreact with activated VEGF receptor 1, but does not react with other related tyrosine phosphorylated tyrosine kinases. Species Crossreactivity: Mouse
DMAb-0041-YY	CBYY-0221	Mouse	Human		Synthetic phosphopeptide corresponding to residues surrounding Tyr951 of human VEGF receptor 2 (KLH)
DMAb-0042-YY	CBYY-0222	Mouse	Human		Recognizes endogenous levels of human VEGFR-2 at ~230kD only when phosphorylated at tyrosine 1175. Does not crossreact with other phosphorylated receptor tyrosine kinases. May crossreact with VEGFR1. Species Crossreactivity: Mouse
DMAb-0043-YY	CBYY-0223	Mouse	Human		Synthetic peptide corresponding to residues surrounding Tyr1175 of human VEGF receptor 2 (KLH). MW: 230kD
DMAb-0044-YY	CBYY-0226	Mouse	Human		Synthetic peptide encompassing the phosphorylated tyrosine residue 1054 of human KDR/Flk-1/VEGFR2. Cellular Localization: Membrane; Single-pass type I membrane protein
DMAb-0045-YY	CBYY-0227	Mouse	Human		Recombinant protein containing the carboxy-terminal 150 amino acid residues of human VEGF receptor 2
DMAb-0046-YY	CBYY-0228	Mouse	Human		KLH-conjugated, synthetic peptide encompassing the phosphorylated tyrosine residue 1054 of human KDR/Flk-1/VEGFR2
DMAb-0047-YY	CBYY-0229	Mouse	Human

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-KDR DNA-encoded mAb (DMAb), pVAX1 (DMAb-1274-YY)

Specifications

Target

Customer Reviews and Q&As

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