Anti-MVP DNA-encoded mAb (DMAb), pVAX1 (DMAb-2504-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-MVP DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
MVP

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
9961

UniProt ID
Q14764

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0012-YJ	1011	Mouse	Human	IgG1	Recognizes human LRP, MVP. Dectected in a large number of eukaryotic cells including the MCF-7 and Hela tumor cell lines.
DMAb-0013-YJ	1014	Mouse	Human	IgG1
DMAb-0014-YJ	1027	Mouse	Human	IgM	Recognize different epitopes of the protein. This 104-kD protein is the major vault protein (MVP) also described as the lung resistance protein (LRP) and has shown to interact with the estrogen receptor.
DMAb-0015-YJ	1032	Mouse		IgM	Recognizes different epitopes of the protein. This 104-kD protein is the major vault protein (MVP) also described as the lung resistance protein (LRP) and has shown to interact with the estrogen receptor.
DMAb-0016-YJ	5F242	Mouse	Human	IgG2b	Reacts with an internal epitope of LRP/Major Vault Protein (P110), which is strongly overexpressed in various human non-P-glycoprotein multidrug-resistance (MDR) tumor cell lines. Not applicable in immunoblot. Species Crossreactivity: Human.
DMAb-0017-YJ	6D535	Mouse	Human	IgG2b	Human MVP/LRP (major vault protein/lung resistance protein).
DMAb-0018-YJ	6D537	Mouse	Human	IgG2b	Human MVP/LRP (major vault protein / lung resistance protein).
DMAb-0019-YJ	LMR5	Rat	Human	IgG
DMAb-0020-YJ	LRP-56	Mouse	Human	IgG2b	LRP, MVP, p1110 glycoprotein.
DMAb-0021-YJ	MVP-37	Mouse	Human	IgG2b	Human non-P-glycoprotein MDR tumor cell lines.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-MVP DNA-encoded mAb (DMAb), pVAX1 (DMAb-2504-FY)

Specifications

Target

Customer Reviews and Q&As

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