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The vector of anti-NR1H2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human NR1H2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-NR1H2 antibody linked to 4-1BB (CD137) and CD3ζ signaling domains. And the vector product was designed for the treatment of Testis cancer.
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Details
Target
NR1H2
Targeting Cell Type
T cell
Targeting Diseases
Testis cancer
Generation
Second
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Lentiviral vector
Receptor Construction
scFv-41BB-CD3ζ
Discription of Signaling Cassetes
41BB CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity. CD3ζ CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
NR1H2; Nuclear Receptor Subfamily 1 Group H Member 2; Ubiquitously-Expressed Nuclear Receptor; Nuclear Receptor NER; LXRB; UNR; NER; Nuclear Receptor Subfamily 1; Group H; Member 2; Steroid Hormone-Nuclear Receptor NER; Nuclear Orphan Receptor LXR-Beta
Introduction
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. NR1H2 binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). NR1H2 regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. NR1H2 interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). NR1H2 also plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex.
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Customer Reviews and Q&As
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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