pCDCAR1 HLAA2/WT1Db126 h(28 FcγRIγ)(CAR-MZ124)

The vector of anti-HLA-A2/WT1Db126 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human HLA-A2/WT1Db126. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-HLA-A2/WT1Db126 antibody linked to FcγRIγ signaling domains. And the vector product was designed for the treatment of Human cancers.


Details


Target
HLA-A2-WT1DB126
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Human cancers
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Retroviral
Receptor Construction
scFv-FcγRIγ
Discription of Signaling Cassetes
FcγR
Fc-gamma receptors (FcγR) are Fc receptors (abbreviated FcR) for antibody IgG. All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing phagocytosis of opsonized (marked) microbes. This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which differ in their antibody affinities due to their different molecular structure.
Antibody Clone
F3
Antibody Host
Human

Target


Gene Name
major histocompatibility complex, class I, A
Official Symbol
HLA-A
Gene ID
Synonyms
HLAA

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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