HLA-A2-WT1DB126

Wilms tumor suppressor gene 1 (WT1) is one of the most important TAAs classified by the National Cancer Institute. WT1, a zinc finger transcription factor, is highly expressed in many solid cancers and leukemia cells, but not in normal tissues (including hematopoietic progenitor and stem cells). Several studies have suggested that WT1 has an essential role in leukemogenesis and tumorigenesis, and it is required to maintain the transformed phenotype/function; therefore, tumor escape from immune surveillance as a result of downregulation of WT1 expression is unlikely to occur, marking WT1 as an attractive and important target for immunotherapy. The WT1Db126 (RMFPNAPYL) peptide was identified by screening the WT1 aa sequence for 9-mer peptides that include major anchormotifs for binding to HLA-A2. In vitro immunization elicits WT1 peptide-specific CTLs that mediate lysis of WT1-expressing tumor cells, indicating that this peptide constitutes a highly immunogenic epitope. HLA-A2-WT1Db126 complex is a target of TCR-like antibodies for anti-WT1Db126 peptide CAR-T cell development.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC266 T cell Second F2 ~8kb Retroviral scFv-CD28-FcγR1γ Human Inquiry
CAR-LC267 T cell Second F3 ~8kb Retroviral scFv-CD28-FcγR1γ Human Inquiry
CAR-MZ123 T cell First F2 ~8kb Retroviral scFv-FcγRIγ Human Inquiry
CAR-MZ124 T cell First F3 ~8kb Retroviral scFv-FcγRIγ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC735 F2 Lentivirus Second scFv (F2)-CD28-FcγR1γ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC736 F3 Lentivirus Second scFv (F3)-CD28-FcγR1γ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC822 F2 Lentivirus First scFv (F2)-FcγRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC823 F3 Lentivirus First scFv (F3)-FcγRIγ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON