Lenti-EGFRvIII CAR (scFv-28BBζ, 139)-VP(VP-CAR-LC696)

The ready-to-use lentiviral particles of Lenti-EGFRvIII CAR (scFv-28BBζ, 139)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (139)-CD28-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
EGFRvIII
Expression Cassette
scFv (139)-CD28-41BB-CD3ζ
Clone
139
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Glioblastoma

Target


Introduction
EGFRvIII is a gain-of-function mutation that arises from genomic deletion of exons 2–7. This deletion leads to a ligand-independent receptor, although the constitutive activity of this receptor is lower than that of ligand-stimulated wtEGFR. Despite this sub-optimal activity, EGFRvIII imparts a significant growth advantage to HGG cells, especially in vivo.
Alternative Names
EGFRvIII; EGFR variant III

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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