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Epidermal growth factor receptor variant III (EGFRvIII) is an extracellular domain mutation of epidermal growth factor receptor (EGFR), which leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRvIII is considerably expressed in glioblastoma multiforme (GBM), which results in overexpression of the transmembrane tyrosine kinase receptor (EGFR). Therefore, EGFRvIII is related to glioblastoma multiforme (GBM).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| XS-0622-ZP3206 | Anti-EGFRvIII h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3378 | Anti-EGFRvIII h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0822-YF1249 | Anti-Human EGFRvIII (XW-329) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-329 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1250 | Anti-Human EGFRvIII (XW-330) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-330 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1251 | Anti-Human EGFRvIII (XW-331) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-331 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1252 | Anti-Mouse EGFRvIII (XW-332) m(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-332 | Rat | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2169 | Anti-Human EGFRvIII (XW-329) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-329 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2170 | Anti-Human EGFRvIII (XW-330) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-330 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2171 | Anti-Human EGFRvIII (XW-331) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-331 | Human | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2172 | Anti-Mouse EGFRvIII (XW-332) m(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-332 | Rat | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2173 | Anti-Human EGFRvIII (XW-333) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-333 | Humanized | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2174 | Anti-Human EGFRvIII (XW-334) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-334 | Humanized | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2175 | Anti-Human EGFRvIII (XW-335) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-335 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2176 | Anti-Human EGFRvIII (XW-336) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-336 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2177 | Anti-Human EGFRvIII (XW-337) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-337 | Humanized | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF8437 | TS-Fluc Anti-Human EGFRvIII scFv (XW-329) CD28-CD3ζ CAR, pCDCAR1 | Human | XW-329 | Mouse | 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | |||
| XS-0822-YF8438 | TS-Fluc Anti-Human EGFRvIII scFv (XW-330) CD28-CD3ζ CAR, pCDCAR1 | Human | XW-330 | Mouse | 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | |||
| XS-0822-YF8439 | TS-Fluc Anti-Human EGFRvIII scFv (XW-331) CD28-CD3ζ CAR, pCDCAR1 | Human | XW-331 | Human | 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | |||
| XS-0822-YF8440 | TS-Fluc Anti-Mouse EGFRvIII scFv (XW-332) CD28-CD3ζ CAR, pCDCAR1 | Mouse | XW-332 | Rat | 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | |||
| XS-0822-YF8441 | TS-Fluc Anti-Human EGFRvIII scFv (XW-333) CD28-CD3ζ CAR, pCDCAR1 | Human | XW-333 | Humanized | 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ | Lentiviral vector |
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